Document Detail

Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: a prospective, randomized study.
MedLine Citation:
PMID:  10911579     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective was to evaluate the effect of aspirin on infertile women with thin endometrium.
METHODS: Patients who had thin endometrium (< or = 8 mm) and intrauterine insemination were divided into the aspirin and nonaspirin groups. Endometrial pattern (trilaminar and nontrilaminar) and thickness, the pulsatility index (PI) and resistance index (RI) of the uterine artery, spiral artery, and ovarian dominant follicles, and pregnancy rates of both groups were measured.
RESULTS: A total of 114 and 122 women were included in the aspirin and nonaspirin groups, respectively. There were significantly higher percentages of trilaminar endometrium (46.5% vs. 26.2%) and pregnancy rate (18.4% vs. 9.0%) after aspirin therapy. There was nonsignificant difference in the endometrial thickness, and PI/RI values of the uterine artery, spiral artery, and ovarian dominant follicle between both groups.
CONCLUSIONS: Higher pregnancy rate and better endometrial pattern were achieved in patients with thin endometrium after aspirin administration. Aspirin therapy could not significantly increase the endometrial thickness and the resistance of uterine and ovarian flow.
Y Y Hsieh; H D Tsai; C C Chang; H Y Lo; C L Chen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  17     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  174-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.
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MeSH Terms
Aspirin / pharmacology,  therapeutic use*
Endometrium / pathology*
Infertility, Female / drug therapy*,  pathology
Insemination, Artificial, Homologous
Pregnancy Rate
Prospective Studies
Reg. No./Substance:

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