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Low dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta-analysis of the literature.
MedLine Citation:
PMID:  22900525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It was hypothesized that low-dose aspirin could improve implantation rates in subsequent pregnancies in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Previous studies have shown inconclusive results or focused on surrogate end-points. We therefore conducted a systematic review and meta-analysis of the literature investigating the effect of low-dose aspirin on hard outcomes including live birth rate, pregnancy rate and miscarriage.MEDLINE and EMBASE databases were searched up to November 2011. Randomized controlled trials comparing low-dose aspirin with placebo/no treatment in IVF/ICSI women were included. Pooled odds Ratios (OR) and 95% confidence intervals (CIs) were calculated. Seventeen studies with 6403 patients were included. The use of aspirin did not improve live birth pregnancy rate compared to placebo or no treatment (1.08, 95% CI 0.90,1.29). Pregnancy rates were significantly increased in patients randomized to low-dose aspirin (OR 1.19, 95% CI 1.01, 1.39), but miscarriage rates were not (OR 1.18, 95% CI 0.82, 1.68). Results of sensitivity analyses including high-quality studies did not show statistically significant differences in all considered end-points. The results of this study do not show a substantial efficacy of aspirin in women undergoing IVF/ICSI and do not support the use of low-dose aspirin to improve the success of IVF/ICSI in terms of pregnancy outcomes. Further high quality studies evaluating the possible efficacy of aspirin in selected groups of patients are warranted. © 2012 International Society on Thrombosis and Haemostasis.
Authors:
F Dentali; W Ageno; E Rezoagli; E Rancan; A Squizzato; S Middeldorp; M Margaglione; E Grandone
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-18
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
Affiliation:
Department of Clinical Medicine, University of Insubria, Varese, Italy. Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands Department of Biomedical Sciences, University of Foggia, Foggia, Italy Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia, Italy.
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