Document Detail

Low dose aspirin in pregnancy: a clinical and biochemical study of effects on the newborn.
MedLine Citation:
PMID:  8229615     Owner:  NLM     Status:  MEDLINE    
Low dose Aspirin in pregnancy reduces the incidence of intra uterine growth retardation (IUGR) and pregnancy induced hypertension (PIH) in women at risk for these complications. To investigate if this drug, even in a low dose, could expose the newborn to hemorrhagic complications, we studied ten neonates whose mothers had been taking 50 mg/day of Aspirin from the 12th week of pregnancy until delivery and compared them with eight newborns whose mothers didn't take the drug. No hemorrhagic complications (emathemesis, ecchymoses or petechiae, subconjunctival hemorrhage, cephaloematomas etc.) were observed in the fetuses exposed to Aspirin or in the control group. No hemorrhagic lesions were found by ultrasound brain scan on the fourth day of life. Newborns exposed to Aspirin showed a significantly lower thromboxane concentration on the first day of life (median 73 ng/ml versus 217 ng/ml); however on the fourth day the level of serum thromboxane in the cases exposed reached the values of the unexposed ones (median 146 ng/ml versus 143 ng/ml). In conclusion low dose Aspirin in pregnancy can be considered a safe drug without and adverse effect on the newborn.
A Valcamonico; M Foschini; M Soregaroli; M Tarantini; T Frusca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  21     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-03     Completed Date:  1993-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
Obstetrics and Gynecology Department, University of Brescia, Italy.
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MeSH Terms
Aspirin / administration & dosage*,  adverse effects*
Birth Weight
Cerebral Hemorrhage / chemically induced*
Fetal Blood / metabolism
Fetal Growth Retardation / prevention & control
Gestational Age
Hypertension / prevention & control
Infant, Newborn
Maternal-Fetal Exchange*
Pregnancy Complications, Cardiovascular / prevention & control
Reference Values
Thromboxane B2 / blood
Reg. No./Substance:
50-78-2/Aspirin; 54397-85-2/Thromboxane B2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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