| Low dose angiotensin II infusions into the renal artery induce chronic hypertension in conscious dogs. | |
| | |
MedLine Citation:
|
PMID: 9116928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Angiotensin II was infused at 0.5 ng/kg/min either directly into the left renal artery (n = 5) or intravenously (n = 4) for 28 days in conscious dogs. Renal artery infusion of angiotensin II had no significant effect on mean arterial pressure after 1 and 24 h, but pressure had increased by 12 +/- 2, 12 +/- 4, 8 +/- 3 and 13 +/- 3 mmHg on days 7, 14, 21 and 28, respectively, during infusion. Renal blood flow decreased significantly at 24 hours (p = 0.02) but was not significantly reduced subsequently. Over days 7-28, central venous pressure and haematocrit rose significantly but body weight did not change significantly. During intravenous infusion of angiotensin II, arterial pressure increased (5 +/- 4, 7 +/- 5 and 5 +/- 3 mmHg on days 7, 14 and 21, respectively), body weight rose and haematocrit fell significantly, but central venous pressure did not change. Thus, angiotensin II infused into the renal artery, at a dose which had no initial pressor effect, produced chronic, stable hypertension, with equivocal evidence of renal fluid retention. We conclude that elevated levels of angiotensin II in the kidney alone can cause chronic hypertension. |
| | |
Authors:
|
S M Fitzgerald; K M Stevenson; R G Evans; W P Anderson |
Related Documents
:
|
14732738 - Endogenous angiotensin and pressure modulate brain angiotensinogen and at1a mrna expres... 415868 - Effects of the angiotensin ii antagonist 1-sar-8-ala-angiotensin ii in hypertension in ... 9683928 - Heparin inhibits mesenteric vascular hypertrophy in angiotensin ii-infusion hypertensio... 8769748 - Evidence that centrally released arginine vasopressin is involved in central pressor ac... 19808338 - Reduction in mitral regurgitation during therapy guided by measured filling pressures i... 1986168 - Studies of myocardial protection in the immature heart. v. safety of prolonged aortic c... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Blood pressure Volume: 6 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1997 Jan |
Date Detail:
|
Created Date: 1997-04-23 Completed Date: 1997-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 52-61 Citation Subset: IM |
Affiliation:
|
Emily E.E. Stewart Renal Laboratory, Baker Medical Research Institute, Melbourne, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
toxicity* Animals Chronic Disease Dogs Dose-Response Relationship, Drug Hypertension, Renal / chemically induced* Infusions, Intra-Arterial Infusions, Intravenous Pilot Projects Renal Artery Renal Circulation / drug effects* Sodium Chloride / metabolism Vascular Resistance / drug effects Vasoconstrictor Agents / toxicity* Water / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 7647-14-5/Sodium Chloride; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intra-arterial blood pressure during exercise and left ventricular indices in normotension and borde...
Next Document: Dynamic vectorcardiography for early diagnosis of acute myocardial infarction compared with 12-lead ...