Document Detail


Low dose angiotensin II infusions into the renal artery induce chronic hypertension in conscious dogs.
MedLine Citation:
PMID:  9116928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin II was infused at 0.5 ng/kg/min either directly into the left renal artery (n = 5) or intravenously (n = 4) for 28 days in conscious dogs. Renal artery infusion of angiotensin II had no significant effect on mean arterial pressure after 1 and 24 h, but pressure had increased by 12 +/- 2, 12 +/- 4, 8 +/- 3 and 13 +/- 3 mmHg on days 7, 14, 21 and 28, respectively, during infusion. Renal blood flow decreased significantly at 24 hours (p = 0.02) but was not significantly reduced subsequently. Over days 7-28, central venous pressure and haematocrit rose significantly but body weight did not change significantly. During intravenous infusion of angiotensin II, arterial pressure increased (5 +/- 4, 7 +/- 5 and 5 +/- 3 mmHg on days 7, 14 and 21, respectively), body weight rose and haematocrit fell significantly, but central venous pressure did not change. Thus, angiotensin II infused into the renal artery, at a dose which had no initial pressor effect, produced chronic, stable hypertension, with equivocal evidence of renal fluid retention. We conclude that elevated levels of angiotensin II in the kidney alone can cause chronic hypertension.
Authors:
S M Fitzgerald; K M Stevenson; R G Evans; W P Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  6     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-23     Completed Date:  1997-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  52-61     Citation Subset:  IM    
Affiliation:
Emily E.E. Stewart Renal Laboratory, Baker Medical Research Institute, Melbourne, Australia.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / toxicity*
Animals
Chronic Disease
Dogs
Dose-Response Relationship, Drug
Hypertension, Renal / chemically induced*
Infusions, Intra-Arterial
Infusions, Intravenous
Pilot Projects
Renal Artery
Renal Circulation / drug effects*
Sodium Chloride / metabolism
Vascular Resistance / drug effects
Vasoconstrictor Agents / toxicity*
Water / metabolism
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 7647-14-5/Sodium Chloride; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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