Document Detail


Low-dose amiodarone for atrial fibrillation.
MedLine Citation:
PMID:  8237834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concerns about proarrhythmia risk and inefficacy associated with class I antiarrhythmic drugs have revived interest in low-dose amiodarone (maintenance dose 200-400 mg/day) for suppression of atrial fibrillation. In nonrandomized trials of amiodarone for atrial fibrillation refractory to conventional agents, amiodarone has been successful in maintaining sinus rhythm in 53-79% of patients during a mean follow-up of 15-27 months. Intolerable side effects, including pulmonary toxicity, are in the range of 1-12% per year and resolve following amiodarone withdrawal in the majority of cases. Proarrhythmia risk associated with amiodarone, even in the setting of left ventricular dysfunction, is extremely low. In patients with congestive heart failure, in whom other pharmacologic options are limited by proarrhythmia risk and negative inotropism, preliminary experience with amiodarone is especially promising. Randomized trials are needed, directly comparing amiodarone to conventional antiarrhythmic therapy for atrial fibrillation suppression and comparing amiodarone to warfarin for thromboembolism prevention in patients with atrial fibrillation refractory to conventional antiarrhythmic drugs.
Authors:
H R Middlekauff; I Wiener; W G Stevenson
Related Documents :
15305784 - Mortality analysis in patients with atrial fibrillation and implantable permanent pacem...
22234674 - Left ventricular endocardial pacing and multisite pacing to improve crt response.
186184 - Cyclic amp as a determinant of vulnerability to ventricular fibrillation in the isolate...
12360154 - Rationale and design of a study assessing treatment strategies of atrial fibrillation i...
8915994 - Electrocardiographic observation on spontaneously occurring arrhythmias in chickens.
22327244 - Successful implantation of heartware hvad left ventricular assist device with concomita...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  72     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75F-81F     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiology, University of California, Los Angeles School of Medicine 90024.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amiodarone / administration & dosage,  adverse effects,  therapeutic use*
Atrial Fibrillation / complications,  drug therapy*
Humans
Chemical
Reg. No./Substance:
1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The CASCADE Study: randomized antiarrhythmic drug therapy in survivors of cardiac arrest in Seattle....
Next Document:  Secondary prevention after myocardial infarction with class III antiarrhythmic drugs.