Document Detail

Low dose aminophylline selectively increases upper airway motor activity in normals.
MedLine Citation:
PMID:  3287534     Owner:  NLM     Status:  MEDLINE    
Because certain pharmacologic agents differentially influence upper airway and diaphragm motor activity, we postulated that the adenosine antagonist theophylline might preferentially increase alae nasi activity in human subjects. Using a double-blinded, randomized, placebo controlled design, we studied the effect of low dose aminophylline (1-2 mg/kg) on alae nasi and diaphragm surface electromyographic (EMG) activity. Seven healthy volunteers served as subjects for two trials on separate days. Subjects breathed from a close circuit while end tidal PCO2 was held constant in the eucapnic range. During each trial we recorded EMG signals from the alae nasi and diaphragm before and after intravenous infusion of either aminophylline or placebo. After the administration of aminophylline, the mean alae nasi EMG signal increased 87 +/- 31 (SD)% (P less than 0.005) while the mean diaphragmatic EMG signal did not change. There was no significant change in either the alae nasi or diaphragmatic EMG signal after placebo. There was no change in minute ventilation, tidal volume, or respiratory frequency after either aminophylline or placebo. We speculate that low dose aminophylline produces a selective increase in upper airway muscle activity through stimulation of the reticular activating system.
K C Lahive; J W Weiss; S E Weinberger
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  72     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-07-01     Completed Date:  1988-07-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
Charles A. Dana Research Institute, Boston, MA.
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MeSH Terms
Aminophylline / administration & dosage,  pharmacology*
Clinical Trials as Topic
Diaphragm / drug effects,  physiology
Double-Blind Method
Muscle Contraction / drug effects
Nose / drug effects,  physiology
Random Allocation
Respiratory Muscles / drug effects*,  physiology
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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