| Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients. | |
MedLine Citation:
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PMID: 20502340 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase blood pressure (BP) and potentially reduce the efficacy of several antihypertensive drugs. We evaluated the effect of low-dose acetylsalicylic acid (ASA) on BP control in drug-treated hypertensive patients in a primary care population. DESIGN/METHODS: Nine hundred and five successive patients aged 25–91 years (mean 65.5 years) from 15 health centers in south-west Finland were studied. The patients were on antihypertensive monotherapy (45.7%) or on combination therapy (54.3%). Office BP was measured twice with a 2-min interval after at least a 10-min rest using an ordinary sphygmomanometer. RESULTS: Patients receiving ASA (n = 246) showed lower diastolic BP (83.9 ± 9.0 vs. 87.0 ± 9.6 mmHg; P < 0.001) compared with those who were not using any NSAIDs (n = 659). No significant difference in systolic BP was observed between the groups. As a result, pulse pressure was slightly higher in the ASA group (66.9 ± 18.9 vs. 63.3 ± 17.7 mmHg, P = 0.01). Mean arterial pressure was lower in the ASA group (106.2 ± 10.6 vs. 108.1 ± 10.4 mmHg, P = 0.02). In a stepwise linear multivariate model, ASA remained a significant predictor of lower diastolic BP even after the adjustment with the confounding effects of age and sex. CONCLUSION: According to our population-based study low-dose ASA does not have deleterious effects on BP control in drug-treated hypertensive patients. |
Authors:
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Veli-Matti Leinonen; Juha Varis; Risto Vesalainen; Johanna Päivärinta; Minna Sillanpää; Ilkka Kantola |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 18 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-06-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 136-40 Citation Subset: IM |
Affiliation:
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Turku University Hospital, Department of Medicine, University of Turku, Faculty of Medicine, Internal Medicine, Finland. veli-matti.leinonen@utu.fi |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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