Document Detail


Low diversity of the gut microbiota in infants with atopic eczema.
MedLine Citation:
PMID:  22153774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts.
OBJECTIVE: We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development.
METHODS: Microbial diversity and composition were analyzed with barcoded 16S rDNA 454-pyrosequencing in stool samples at 1 week, 1 month, and 12 months of age in 20 infants with IgE-associated eczema and 20 infants without any allergic manifestation until 2 years of age (ClinicalTrials.gov ID NCT01285830).
RESULTS: Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P = .004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P = .02 and P = .01) and the phylum Proteobacteria at 12 months of age (P = .02). The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability. At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation (Empirical Analysis of Digital Gene Expression in R [edgeR] test: P = .008, q = 0.02).
CONCLUSION: Low intestinal microbial diversity during the first month of life was associated with subsequent atopic eczema.
Authors:
Thomas R Abrahamsson; Hedvig E Jakobsson; Anders F Andersson; Bengt Björkstén; Lars Engstrand; Maria C Jenmalm
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-06
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  129     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-04-12     Revised Date:  2013-02-07    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-40, 440.e1-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden. thomas.abrahamsson@lio.se
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01285830
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Bacteria / classification,  genetics
Child, Preschool
DNA, Bacterial / analysis
Eczema / diagnosis,  microbiology*,  prevention & control
Feces / microbiology
Female
Food Hypersensitivity / blood,  diagnosis,  immunology
Humans
Hypersensitivity / diagnosis,  microbiology*,  prevention & control
Immunoglobulin E / blood
Infant
Infant, Newborn
Intestines / microbiology*
Male
Probiotics / therapeutic use
RNA, Ribosomal, 16S / genetics
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/Allergens; 0/DNA, Bacterial; 0/RNA, Ribosomal, 16S; 37341-29-0/Immunoglobulin E
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2012 Feb;129(2):441-2   [PMID:  22284932 ]
J Allergy Clin Immunol. 2013 Jan;131(1):247-8   [PMID:  23199602 ]
J Allergy Clin Immunol. 2013 Jan;131(1):248-9   [PMID:  23199606 ]

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