Document Detail


Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure.
MedLine Citation:
PMID:  19723834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Age and increasing systolic blood pressure (BP) are associated with vascular endothelial dysfunction, but the factors involved are incompletely understood. We tested the hypothesis that vascular endothelial function is related to dietary sodium intake among middle-aged and older adults (MA and O) with elevated systolic BP.
METHODS: Data were analyzed on 25 otherwise healthy adults aged 48-73 years with high normal systolic BP or stage I systolic hypertension (130-159 mmHg). Self-reported sodium intake was <100 mmol/d in 12 (7 M) subjects (low sodium, 73+/-6 mmol/d) and between 100 and 200 mmol/d in 13 (9 M) subjects (normal sodium, 144+/-6 mmol/d).
RESULTS: Groups did not differ in other dietary factors, age, body weight and composition, BP, metabolic risk factors, physical activity and maximal aerobic capacity. Plasma concentrations of norepinephrine, endothelin-1, oxidized low-density lipoproteins (LDL), antioxidant status and inflammatory markers did not differ between groups. Brachial artery flow-mediated dilation (FMD) was 42% (mm Delta) to 52% (% Delta) higher in the low versus normal sodium group (p < 0.05). In all subjects, brachial artery FMD was inversely related to dietary sodium intake (FMD mm Delta r =-0.40, p < 0.05; %Delta r =-0.53, p < 0.01). Brachial artery FMD was not related to any other variable. In contrast, endothelium-independent dilation did not differ between groups (p >or= 0.24) and was not related to sodium intake in the overall group (p >or= 0.29).
CONCLUSIONS: Low sodium intake is associated with enhanced brachial artery FMD in MA and O with elevated systolic BP. These results suggest that dietary sodium restriction may be an effective intervention for improving vascular endothelial function in this high-risk group.
Authors:
Kristen L Jablonski; Phillip E Gates; Gary L Pierce; Douglas R Seals
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-01
Journal Detail:
Title:  Therapeutic advances in cardiovascular disease     Volume:  3     ISSN:  1753-9447     ISO Abbreviation:  Ther Adv Cardiovasc Dis     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-11-24     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101316343     Medline TA:  Ther Adv Cardiovasc Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-56     Citation Subset:  IM    
Affiliation:
Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA. Kristen.Jablonski@colorado.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Biological Markers / blood
Blood Pressure*
Brachial Artery / physiopathology*
Diet Records
Diet, Sodium-Restricted*
Endothelium, Vascular / physiopathology*
Female
Humans
Hypertension / blood,  diet therapy*,  etiology,  physiopathology
Male
Middle Aged
Regional Blood Flow
Severity of Illness Index
Sodium Chloride, Dietary / adverse effects*
Vasodilation*
Grant Support
ID/Acronym/Agency:
AG000279/AG/NIA NIH HHS; AG006537/AG/NIA NIH HHS; AG013038/AG/NIA NIH HHS; AG022241/AG/NIA NIH HHS; AG033994/AG/NIA NIH HHS; F31 AG033994/AG/NIA NIH HHS; RR00051/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Sodium Chloride, Dietary
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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