Document Detail

Low diastolic pressure and risk of dementia in very old people: a longitudinal study.
MedLine Citation:
PMID:  19752556     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIM: Midlife high blood pressure is linked to late-life dementia. We sought to investigate the temporal relation of blood pressure to the risk of dementia and Alzhei-mer's disease (AD) among older adults. METHODS: A dementia-free cohort (n = 422) aged > or =81 years was followed for 3 years to detect dementia and AD cases (Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised criteria). The blood pressure was measured 4 times over a 9-year period starting from > or =75 years of age. The data were analyzed with Cox models controlling for potential confounders. RESULTS: During the 954 person-years of follow- up, 89 subjects developed dementia (72 AD cases). Low diastolic pressure (<70 vs. 70-89 mm Hg) was associated with a multiadjusted hazard ratio of 2.13 [95% confidence interval (CI) = 1.05-4.32] for dementia and 2.16 (95% CI = 0.98-4.73) for AD occurring over a 6-to 9-year period, whereas high diastolic pressure (> or =90 mm Hg) was marginally related to a decreased hazard ratio of 0.58 (95% CI = 0.33-1.02) for dementia and 0.57 (95% CI = 0.30-1.09) for AD. Systolic pressure was not significantly related to dementia risk. Subjects who developed dementia had a greater decline in blood pressure than persons who did not, mainly during the 3-year period before dementia diagnosis. CONCLUSION: Low diastolic pressure predicts the risk of dementia among very old people, and the blood pressure exhibits a substantial decline over around 3 years before the dementia syndrome becomes clinically evident.
Chengxuan Qiu; Bengt Winblad; Laura Fratiglioni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-12
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  28     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-23     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet-Stockholm University, Stockholm, Sweden.
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MeSH Terms
Aged / physiology*
Aged, 80 and over / physiology*
Alzheimer Disease / epidemiology,  physiopathology,  psychology
Antihypertensive Agents / adverse effects
Apolipoprotein E4 / genetics
Blood Pressure / physiology*
Cohort Studies
Dementia / epidemiology*,  physiopathology*,  psychology
Longitudinal Studies
Neuropsychological Tests
Proportional Hazards Models
Socioeconomic Factors
Sweden / epidemiology
Vascular Diseases / epidemiology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Apolipoprotein E4

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