Document Detail

Low-density lipoproteins in patients homozygous for familial hyperbetalipoproteinaemia.
MedLine Citation:
PMID:  183929     Owner:  NLM     Status:  MEDLINE    
1. The low-density lipoproteins (LDL; density 1-007-1-063 g/ml) from two patients homozygous for familial hyperbetalipoproteinaemia have been submitted to chemical and physicochemical analysis. 2. The presence of an anomalous lipoprotein with a low proportion of triglyceride and a raised proportion of cholesterol has been confirmed. 3. In one patient, this lipoprotein accounted for about 85% of the LDL, but in the second, the amount varied from about 85% to a point at which it could not be detected among the coexisting normal lipoproteins. 4. The protein moiety of this anomalous LDL has effectively the same amino acid composition as that derived from the LDL of healthy subjects. 5. The proportions of carbohydrate, phospholipid and fatty acids could not be reliably distinguished from those of normal LDL. 6. The molecular weight and diffusion constant of the abnormal lipoprotein, even in the purest preparation, were close to the values determined for normal LDL of similar flotation rate.
G L Mills; C E Taylaur; M J Chapman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  51     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-31     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood
Cholesterol Esters / blood
Hyperlipidemias / blood*,  genetics*
Lipoproteins, LDL / blood*
Microscopy, Electron
Molecular Weight
Phospholipids / blood
Protein Conformation
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol Esters; 0/Lipoproteins, LDL; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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