| Low-density lipoprotein particle size decreases during normal pregnancy in association with triglyceride increases. | |
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MedLine Citation:
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PMID: 9773399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterize the changes in low-density lipoprotein (LDL) peak particle diameter (diameter of the predominant LDL subclass) in relation to changes in serum triglyceride concentration during successive stages of normal gestation and postpartum. METHODS: Nonfasting venous blood was obtained longitudinally during and after uncomplicated primiparous pregnancy from 10 nonsmoking women with no history of metabolic disorders. Plasma LDL diameter was determined by nondenaturing polyacrylamide gel electrophoresis. Serum concentrations of total cholesterol, triglyceride, apolipoprotein B, apolipoprotein A-I, and LDL-cholesterol were measured. Gestational changes were analyzed by one-way repeated-measures analysis of variance and the paired multiple comparison Student-Newman-Keuls test. Pearson coefficients were computed for correlation of serum lipids and LDL diameter. RESULTS: Low-density lipoprotein diameter decreased progressively with advancing gestation, evident by 16-20 weeks relative to 5-12 weeks. Seven of 10 cases were subclass pattern B (diameter less than 255 A) by term, indicating that small, dense particles predominated. The average diameter decrease from early to late gestation was 13 A. All subjects reverted to subclass pattern A (diameter 255 A or more) by 6-12 weeks postpartum, indicating prevalence of large, buoyant LDL. Low-density lipoprotein diameter correlated inversely with concentrations of serum triglyceride (r = -.61, P < .0001), apo B (r = -.66, P < .0001), cholesterol (r = -.53, P < .001), LDL cholesterol (r = -.45, P < .005), and apo A-I (r = -.39, P < .02). CONCLUSION: Gestational triglyceride increases are accompanied by progressive decreases in LDL diameter in a majority of cases. These changes undergo reversal postpartum and therefore are transient. Small, dense LDL particles have a number of properties capable of altering vascular function. However, the consequences of the gestational LDL size decrease for maternal and fetal metabolism remain unknown. |
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Authors:
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C A Hubel; Y Shakir; M J Gallaher; M K McLaughlin; J M Roberts |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the Society for Gynecologic Investigation Volume: 5 ISSN: 1071-5576 ISO Abbreviation: J. Soc. Gynecol. Investig. Publication Date: 1998 Sep-Oct |
Date Detail:
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Created Date: 1998-12-15 Completed Date: 1998-12-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9433806 Medline TA: J Soc Gynecol Investig Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 244-50 Citation Subset: IM |
Affiliation:
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Magee-Womens Research Institute, Pittsburgh, PA 15213, USA. hubelc+@pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein A-I
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metabolism Apolipoproteins B / blood Cholesterol / blood Cholesterol, LDL / blood Electrophoresis, Polyacrylamide Gel Female Gestational Age Humans Lipoproteins, LDL / blood* Particle Size Pregnancy / blood* Triglycerides / blood* |
| Grant Support | |
ID/Acronym/Agency:
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1 RO3 HD34799/HD/NICHD NIH HHS; P01 HD30367/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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