| Low density lipoprotein-containing circulating immune complexes and coronary atherosclerosis. | |
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MedLine Citation:
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PMID: 2369935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood serum of most patients with coronary heart disease (CHD) caused a 2- to 5-fold increase in the lipid content of smooth muscle cells cultured from unaffected human aortic intima, i.e., possessed an atherogenic potential manifested in culture. Treatment of the CHD patients' serum with 2.5% polyethylene glycol 6000 removed the circulating immune complexes. The serum subjected to this treatment lost its atherogenic properties, i.e., failed to increase the content of lipids in cultured cells. Incubation of smooth muscle cells derived from human aortic intima with circulating immune complexes isolated from an atherogenic patient's serum caused a 1.5- to 3-fold rise in the intracellular cholesterol. Circulating immune complexes contained apolipoprotein B (apo B), but not apolipoproteins A1 and E. The apo B content strongly correlated with the total cholesterol content. The cholesterol/apo B ratio of the complexes was characteristic of low density lipoproteins (LDL), but not of very low density lipoproteins or intermediate density lipoproteins. The composition of the main lipid classes in these complexes was similar to that in LDL. Blood sera of most (90%) CHD patients was characterized by a high cholesterol and apolipoprotein B content in circulating immune complexes. The ability of these sera to induce lipid accumulation in cultured cells directly correlated with the cholesterol and apolipoprotein B level of circulating immune complexes (r = 0.91). These findings suggest that the atherogenic potential of CHD patients' blood serum is due to LDL-containing immune complexes. |
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Authors:
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V V Tertov; A N Orekhov; A G Kacharava; I A Sobenin; N V Perova; V N Smirnov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental and molecular pathology Volume: 52 ISSN: 0014-4800 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-08-21 Completed Date: 1990-08-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 300-8 Citation Subset: IM |
Affiliation:
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USSR Cardiology Research Center, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigen-Antibody Complex* Apolipoproteins B / metabolism Arteriosclerosis / etiology* Cells, Cultured Coronary Disease / blood* Female Humans Lipoproteins, LDL / blood*, immunology Male Middle Aged Muscle, Smooth, Vascular / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Apolipoproteins B; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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