| Low-density lipoprotein apheresis in a pediatric patient with refractory nephrotic syndrome due to focal segmental glomerulosclerosis. | |
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MedLine Citation:
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PMID: 19444573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Focal segmental glomerulosclerosis (FSGS) often leads to refractory nephrotic syndrome (NS). A high level of low-density lipoprotein (LDL) is a risk factor for the progression of NS. An 8-year-old girl presented with severe proteinuria refractory to steroid therapy. She was diagnosed with non-IgA diffuse mesangial proliferative glomerulonephritis. Oral prednisolone, methylprednisolone (mPL) pulse therapy, and cyclosporine and cyclophosphamide therapy failed to achieve remission. Follow-up renal biopsy revealed FSGS. Her serum level of LDL was high, and LDL-apheresis (LDL-A) was performed five times, followed by mPL pulse therapy. Urinary protein decreased from 2-4 g x day(-) to 0.5-1.0 g x day(-). LDL-A may be beneficial in the treatment of multidrug-resistant FSGS. |
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Authors:
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Jun Oto; Kenichi Suga; Sato Matsuura; Shuji Kondo; Yoshiaki Ohnishi; Daisuke Inui; Hideaki Imanaka; Shoji Kagami; Masaji Nishimura |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-05-15 |
Journal Detail:
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Title: Journal of anesthesia Volume: 23 ISSN: 1438-8359 ISO Abbreviation: J Anesth Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
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Languages: eng Pagination: 284-7 Citation Subset: IM |
Affiliation:
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Department of Emergency and Critical Care Medicine, Tokushima University Hospital, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Blood Component Removal / methods* Child Drug Resistance Female Glomerulosclerosis, Focal Segmental / complications*, pathology Humans Immunosuppressive Agents / therapeutic use Kidney / pathology Lipoproteins, LDL / blood* Nephrotic Syndrome / etiology*, pathology, therapy* Proteinuria / etiology Pulse Therapy, Drug |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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