Document Detail


Low density lipoprotein (LDL) subfractions during pregnancy: accumulation of buoyant LDL with advancing gestation.
MedLine Citation:
PMID:  11134106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy is accompanied by changes in the maternal lipoprotein metabolism that may serve to satisfy the nutritional demands of the fetus. In this study lipoprotein metabolism was investigated in 23 women during normal pregnancy in the first, second, and third trimesters and in 15 healthy nonpregnant women with regular menstrual cycles. Lipid and apolipoprotein concentrations were measured in total plasma, very low density, intermediate density, low density (LDL), and high density lipoproteins, and in each of six LDL subfractions. During early pregnancy, triglycerides, and dense LDL were higher than in the nonpregnant state. With advancing gestation, triglycerides increased and the distribution of apolipoprotein B-100-containing lipoproteins became increasingly dominated by the accumulation of very low density and intermediate density lipoproteins and buoyant, triglyceride-rich LDL. This is the first study that investigates LDL subfractions in pregnancy using a method that strictly separates LDL subfractions by virtue of density. The accumulation of buoyant, triglyceride-rich lipoproteins may be related to the down-regulation of maternal lipase activities by placental hormones. As a consequence, the metabolic changes of late pregnancy may result in an increased flux of lipoprotein-derived lipids to the placenta, which, with advancing gestation, increasingly expresses receptors with a high affinity for triglyceride-rich lipoproteins.
Authors:
K Winkler; B Wetzka; M M Hoffmann; I Friedrich; M Kinner; M W Baumstark; H Wieland; W März; H P Zahradnik
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  85     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4543-50     Citation Subset:  AIM; IM    
Affiliation:
Departments of Clinical Chemistry, University of Freiburg, D-79106 Freiburg, Germany. kwinkler@ukl.uni-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteriosclerosis / blood
Carrier Proteins / blood
Cholesterol / blood
Cholesterol Ester Transfer Proteins
Estradiol / blood
Female
Glycoproteins*
Humans
Lipoproteins, LDL / blood*
Particle Size
Phenotype
Pregnancy / blood*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Ultracentrifugation
Chemical
Reg. No./Substance:
0/CETP protein, human; 0/Carrier Proteins; 0/Cholesterol Ester Transfer Proteins; 0/Glycoproteins; 0/Lipoproteins, LDL; 50-28-2/Estradiol; 57-88-5/Cholesterol

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