Document Detail


Low density lipoprotein (LDL)-mediated suppression of Lewis lung carcinoma in hypercholesterolemic LDL receptor-deficient mice.
MedLine Citation:
PMID:  10049716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An inverse relationship has been reported between cancer risk and cholesterol level, prompting the hypothesis that hypercholesterolemia may be protective against cancer. We tested this hypothesis by evaluating the growth of Lewis lung carcinoma in three different murine models of hypercholesterolemia: Pluronic treated mice, apolipoprotein E (ApoE) deficient mice, and low density lipoprotein receptor (LDL-R) deficient mice. Only the accumulation of LDL-cholesterol in LDL-R deficient mice suppressed tumor growth. Accumulation of chylomicrons, very low density lipoproteins (VLDL), and cholesterol-enriched remnants in the Pluronic treated mice and ApoE deficient mice did not inhibit tumor growth, even though mice in all three models were equally hypercholesterolemic. Taken together, the experimental evidence from our studies indicate that high plasma cholesterol in the form of LDL-cholesterol could have a beneficial effect against cancer in vivo.
Authors:
V N Trieu; F M Uckun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  255     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-81     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Affiliation:
Department of Cardiovascular Biology, Department of Molecular Epidemiology, Hughes Institute, St. Paul, Minnesota 55113, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology
Carcinoma, Lewis Lung / etiology,  metabolism,  prevention & control*
Cholesterol, LDL / pharmacology*
Growth Inhibitors / pharmacology*
Humans
Hypercholesterolemia / genetics*,  metabolism*
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Neoplasm Transplantation
Neovascularization, Pathologic / complications
Receptors, LDL / deficiency*,  genetics
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cholesterol, LDL; 0/Growth Inhibitors; 0/Receptors, LDL

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