Document Detail

Low degree of anesthesia increases the risk of neurogenic pulmonary edema development.
MedLine Citation:
PMID:  17693037     Owner:  NLM     Status:  MEDLINE    
Neurogenic pulmonary edema is an acute life-threatening complication following central nervous system injury. The exact pathogenic mechanism leading to its development is still unclear. We introduce a new hypothesis that high levels of anesthesia might protect the organism against the development of neurogenic pulmonary edema due to a more pronounced inhibition of the hypothalamic, brainstem and spinal vasoactive sympathetic centers. On the basis of a more pronounced neuronal inhibition of the vasoactive centers, a severe sympathetic discharge does not occur and neurogenic pulmonary edema does not develop. In contrast, an insufficient anesthesia level is not able to inhibit the sympathetic nervous system during an injury of the central nervous system and thus neurogenic pulmonary edema develops. During experiments with central nervous system injury, low-anesthesia-induced neurogenic pulmonary edema might negatively influence the overall recovery of the animal. More importantly, during a neurosurgical intervention, insufficient anesthesia might similarly lead to neurogenic pulmonary edema development in operated patients. Our hypothesis indicates the necessity of precisely monitoring of the level anesthesia during experimental manipulations of the central nervous system in animals or neurosurgical interventions in humans.
J Sedý; K Likavcanová; L Urdziková; J Zicha; J Kunes; A Hejcl; P Jendelová; E Syková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-10
Journal Detail:
Title:  Medical hypotheses     Volume:  70     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM    
Institute of Experimental Medicine, ASCR, Prague, Czech Republic.
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MeSH Terms
Anesthesia / adverse effects*,  methods
Central Nervous System / injuries*,  physiopathology
Intracranial Hypertension / physiopathology
Models, Biological
Pulmonary Edema / etiology*,  physiopathology
Sympathetic Nervous System / physiopathology
Vasomotor System / physiopathology

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