| Low-cost protocol for the production of autologous serum eye drops by blood collection and processing centres for the treatment of ocular surface diseases. | |
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MedLine Citation:
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PMID: 21371142 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: To create a low-cost protocol for the production of autologous serum eye drops (ASEs) by blood collection and processing centres using standard equipment and staff already available. The protocol must observe local and federal regulatory authorities' requirements for good manufacturing practice. Aim: The final aim is to improve accessibility to ASEs for patients who need them and to implement similar production parameters at all institutions producing ASEs. Background: Despite evidence of the beneficial effects of ASEs in the treatment of severe ocular surface diseases, ASEs are not approved by most federal regulatory bodies in the United States or Europe. In some countries, such as the United States, access to ASEs is extremely limited and cost-prohibitive. Blood processing centres are in optimal position to help in increasing accessibility and lowering the cost of these products. Materials/Methods: Standard blood processing equipment, staff and materials were chosen for the protocol. The protocol was designed to minimise the risk of contamination as much as possible. Results: A low-cost, open system protocol for production of ASEs was generated that can be implemented by most blood collection and processing centres in the United States and Europe. Conclusion: Efforts should be made to propagate a similar protocol for the production of ASEs in blood centres capable of collecting and processing blood products, making this service affordable and uniformly accessible to patients. |
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Authors:
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A Partal; E Scott |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-3 |
Journal Detail:
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Title: Transfusion medicine (Oxford, England) Volume: - ISSN: 1365-3148 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301182 Medline TA: Transfus Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Transfusion Medicine © 2011 British Blood Transfusion Society. |
Affiliation:
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Department of Ophthalmology, Cornea and External Disease, University of Tennessee Health Sciences Center, Hamilton Eye Institute, Memphis, Tennessee, USA Key Biologics, Memphis, Tennessee, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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