Document Detail

Low coronary flow velocity and shear stress predict restenosis after sirolimus-eluting stent implantation.
MedLine Citation:
PMID:  19263268     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study sought to assess predictive values of coronary flow velocity and an index of shear stress throughout the vessel for angiographic restenosis after sirolimus-eluting stent implantation. DESIGN: The study patients underwent successful implantation of a sirolimus-eluting stent for de novo lesions located in native coronary vessels and underwent follow-up angiography 6-9 months later. The TIMI frame count method and quantitative digital angiographic analysis were performed based on the post-stenting angiogram. Coronary flow velocity and Reynolds number, an index of shear stress, were measured. RESULTS: Post-stenting digital angiograms from 267 patients were analyzed. We divided the study patients into two groups: a Restenosis group with 21 patients and a Non-Restenosis group with 246 patients. The Restenosis group indicated significantly lower coronary flow velocity (137.7+/-35.6 mm/sec versus 241.1+/-72.9 mm/sec, p = 0.0001) and lower Reynolds number (107.0+/-35.8 versus 199.2+/-67.1, p = 0.0001) than did the Non-Restenosis group. CONCLUSIONS: Lowered coronary flow velocity and shear stress after sirolimus-eluting stenting may predict the risk of restenosis.
Hiroyuki Hikita; Akira Sato; Toshihiro Nozato; Tomoyuki Kawashima; Yoshihide Takahashi; Taishi Kuwahara; Atsushi Takahashi
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  43     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2009  
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-303     Citation Subset:  IM    
Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Kanagawa, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*,  instrumentation*
Blood Flow Velocity
Cardiovascular Agents / administration & dosage*
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease / physiopathology,  radiography,  therapy*
Coronary Circulation*
Coronary Restenosis / etiology*,  physiopathology,  radiography
Drug-Eluting Stents*
Middle Aged
Prosthesis Design
Regression Analysis
Risk Assessment
Risk Factors
Sirolimus / administration & dosage*
Stress, Mechanical
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Cardiovascular Agents; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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