| Low coronary flow velocity and shear stress predict restenosis after sirolimus-eluting stent implantation. | |
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MedLine Citation:
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PMID: 19263268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study sought to assess predictive values of coronary flow velocity and an index of shear stress throughout the vessel for angiographic restenosis after sirolimus-eluting stent implantation. DESIGN: The study patients underwent successful implantation of a sirolimus-eluting stent for de novo lesions located in native coronary vessels and underwent follow-up angiography 6-9 months later. The TIMI frame count method and quantitative digital angiographic analysis were performed based on the post-stenting angiogram. Coronary flow velocity and Reynolds number, an index of shear stress, were measured. RESULTS: Post-stenting digital angiograms from 267 patients were analyzed. We divided the study patients into two groups: a Restenosis group with 21 patients and a Non-Restenosis group with 246 patients. The Restenosis group indicated significantly lower coronary flow velocity (137.7+/-35.6 mm/sec versus 241.1+/-72.9 mm/sec, p = 0.0001) and lower Reynolds number (107.0+/-35.8 versus 199.2+/-67.1, p = 0.0001) than did the Non-Restenosis group. CONCLUSIONS: Lowered coronary flow velocity and shear stress after sirolimus-eluting stenting may predict the risk of restenosis. |
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Authors:
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Hiroyuki Hikita; Akira Sato; Toshihiro Nozato; Tomoyuki Kawashima; Yoshihide Takahashi; Taishi Kuwahara; Atsushi Takahashi |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 43 ISSN: 1651-2006 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 298-303 Citation Subset: IM |
Affiliation:
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Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Kanagawa, Japan. hhikita-circ@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*, instrumentation* Blood Flow Velocity Cardiovascular Agents / administration & dosage* Chi-Square Distribution Coronary Angiography Coronary Artery Disease / physiopathology, radiography, therapy* Coronary Circulation* Coronary Restenosis / etiology*, physiopathology, radiography Drug-Eluting Stents* Female Humans Japan Male Middle Aged Prosthesis Design Regression Analysis Risk Assessment Risk Factors Sirolimus / administration & dosage* Stress, Mechanical Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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