Document Detail


Low concentrations of thrombin-inhibitor complexes and the risk of preterm delivery.
MedLine Citation:
PMID:  20510913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: High maternal concentrations of thrombin-antithrombin (TAT) complexes have been associated with adverse outcomes. The objective of this study was to evaluate the relationship between TAT in asymptomatic subjects at 24 and 28 weeks and spontaneous preterm birth (SPTB). STUDY DESIGN: A secondary analysis of the National Institute of Child Health and Human Development Preterm Prediction Study was performed. Subjects with SPTB were matched to controls. Maternal TAT concentrations were previously measured at 24 and 28 weeks. Differences between cases and controls were analyzed with Mann-Whitney U and logistic regression. RESULTS: TAT was lower in cases than controls at 28 weeks (P = .01). The odds ratio for SPTB with TAT less than 25% was 2.55 (95% confidence interval, 1.34-4.89) when adjusted for clinical variables. CONCLUSION: Early third-trimester TAT was lower in subsequent cases of SPTB. In some patients, low TAT concentrations may represent impaired thrombin activation and be pathologic.
Authors:
David N Hackney; Janet M Catov; Hyagriv N Simhan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithrombin III
Biological Markers / blood
Case-Control Studies
Confidence Intervals
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Kaplan-Meiers Estimate
Obstetric Labor, Premature / blood*,  mortality*
Odds Ratio
Peptide Hydrolases / blood*
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Second
Probability
Risk Assessment
Survival Rate
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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