| Low chemoresponsiveness and inadequate hyperventilation contribute to exercise-induced hypoxemia. | |
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MedLine Citation:
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PMID: 7592220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Is inadequate hyperventilation a cause of the exercise-induced hypoxemia observed in some athletes during intense exercise? If so, is this related to low chemoresponsiveness? To test the hypothesis that exercise-induced hypoxemia, inadequate hyperventilation, and chemoresponsiveness are related, 36 nonsmoking healthy men were divided into hypoxemic (Hyp; n = 13) or normoxemic (Nor; n = 15) groups based on arterial oxygen saturation (SaO2; Hyp < or = 90%, Nor > 92%) observed during maximum O2 uptake (VO2max). Men with intermediate SaO2 values (n = 8) were only included in correlation analysis. Ventilatory parameters were collected at rest, during a treadmill maximal oxygen consumption (VO2max) test, and during a 5-min run at 90% VO2max. Chemoresponsiveness at rest was assessed via hypoxic ventilatory response (HVR) and hypercapnic ventilatory response (HCVR). VO2max was not significantly different between Nor and Hyp. SaO2 was 93.8 +/- 0.9% (Nor) and 87.7 +/- 2.0% (Hyp) at VO2max. End-tidal PO2 and the ratio of minute ventilation to oxygen consumption (VE/VO2) were lower while PETCO2 was higher for Hyp (P < or = 0.01). End-tidal PO2, end-tidal PCO2, and VE/VO2 correlated (P < or = 0.05) to SaO2 (r = 0.84, r = -0.70, r = 0.72, respectively), suggesting that differences in oxygenation were due to differences in ventilation. HVR and HCVR were significantly lower for Hyp. HVR was related to VE/VO2 (r = 0.43), and HCVR was related to the ratio of VE to CO2 production at VO2max (r = 0.61).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C A Harms; J M Stager |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 79 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-12-18 Completed Date: 1995-12-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 575-80 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, Indiana University, Bloomington 47405, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / physiopathology* Blood Gas Analysis Chemoreceptor Cells / physiology* Exercise / physiology* Exercise Test Humans Hypercapnia / physiopathology Hyperventilation / physiopathology* Male Oxygen Consumption / physiology Respiratory Mechanics / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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