| Low central venous pressure with milrinone during living donor hepatectomy. | |
| | |
MedLine Citation:
|
PMID: 20420642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Maintaining a low central venous pressure (CVP) has been frequently used in liver resections to reduce blood loss. However, decreased preload carries potential risks such as hemodynamic instability. We hypothesized that a low CVP with milrinone would provide a better surgical environment and hemodynamic stability during living donor hepatectomy. Thirty-eight healthy adult liver donors were randomized to receive either milrinone (milrinone group, n = 19) or normal saline (control group, n = 19) infusion during liver resection. The surgical field was assessed using a four-point scale. Intraoperative vital signs, blood loss, the use of vasopressors and diuretics and postoperative laboratory data were compared between groups. The milrinone group showed a superior surgical field (p < 0.001) and less blood loss (142 +/- 129 mL vs. 378 +/- 167 mL, p < 0.001). Vital signs were well maintained in both groups but the milrinone group required smaller amounts of vasopressors and less-frequent diuretics to maintain a low CVP. The milrinone group also showed a more rapid recovery pattern after surgery. Milrinone-induced low CVP improves the surgical field with less blood loss during living donor hepatectomy and also has favorable effects on intraoperative hemodynamics and postoperative recovery. |
| | |
Authors:
|
H-G Ryu; F S Nahm; H-M Sohn; E-J Jeong; C-W Jung |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
|
Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: 10 ISSN: 1600-6143 ISO Abbreviation: Am. J. Transplant. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-27 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: United States |
Other Details:
|
Languages: eng Pagination: 877-82 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Pressure
/
drug effects* Hepatectomy* Humans Living Donors* Milrinone / pharmacology, therapeutic use* Vasodilator Agents / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 78415-72-2/Milrinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk of colorectal carcinoma in post-liver transplant patients: a systematic review and meta-analysi...
Next Document: Once daily calcineurin inhibitor monotherapy in pediatric liver transplantation.