Document Detail

Low calcium-induced epileptiform activity in hippocampal slices from infant rats.
MedLine Citation:
PMID:  2776301     Owner:  NLM     Status:  MEDLINE    
Ca2+-free solutions evoke spontaneous epileptiform activity in area CA1 of hippocampal slices from adult and young rats at the age of 7/8, 14/15 and 23/24 days. Studies with combined Ca2+-selective and K+-selective microelectrodes showed that this epileptiform activity commenced at higher Ca2+ levels in young than in adult animals. Unlike in disinhibition seizures, [K+]o did not rise to abnormally high levels. We further found that Ca2+ washout curves from young animals were much faster than those from adult slices, suggesting that the extracellular space is wider in young animals than in adult ones.
D Albrecht; U Heinemann
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  48     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  316-20     Citation Subset:  IM    
Institute of Neurophysiology, University of Cologne, Cologne, F.R.G.
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MeSH Terms
Aging / physiology*
Animals, Newborn
Calcium / physiology*
Epilepsy / physiopathology*
Hippocampus / growth & development,  physiopathology*
Reg. No./Substance:

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