Document Detail


Low bone density and low serum levels of soluble RANK ligand are associated with severe arterial calcification in patients with Takayasu arteritis.
MedLine Citation:
PMID:  16219645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Takayasu arteritis (TA) is a chronic inflammatory disorder affecting the aorta and its branches. Vascular calcification has been described in 29-54% of cases of TA, although its aetiology remains unknown. Recently the osteoprotegerin/RANKL/RANK system has emerged as an important contributing factor to atherogenesis and osteogenesis. Our aim is to investigate the association between vascular calcification, bone mineral density (BMD) and the osteoprotegerin/RANK/RANKL system in TA. METHODS: Thirty pre-menopausal female TA patients and 30 age- and sex-matched controls were studied. BMD was measured by dual X-ray absorptiometry. Arterial calcification in TA patients was analysed by computed tomography in thoracic and abdominal sites. Serum levels of osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand (sRANKL) were quantified by enzyme-linked immunosorbent assay. RESULTS: Patients with severe arterial calcification showed lower BMD values than controls in lumbar spine (0.965 +/- 0.055 vs 1.126 +/- 0.153 g/cm2, P = 0.009) and total body (0.993 +/- 0.065 vs 1.085 +/- 0.082 g/cm2, P = 0.019). In contrast, TA patients without calcification presented BMD values similar to controls (P > 0.05). Interestingly, lower serum levels of sRANKL (1.89 +/- 2.35 vs 2.80 +/- 2.23 pg/ml, P = 0.031) and a longer disease duration (12.20 +/- 6.61 vs 3.56 +/- 5.33 yr, P = 0.004) were observed in TA patients with severe calcification compared with patients without calcification. CONCLUSIONS: Severe arterial calcification in TA is associated with low values of BMD and sRANKL, reinforcing the possible link between bone and vascular disease.
Authors:
M C Bezerra; G D Calomeni; V F Caparbo; E S Gebrim; M S Rocha; R M R Pereira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-11
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  44     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1503-6     Citation Subset:  AIM; IM    
Affiliation:
Divisions of Rheumatology, School of Medicine, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aortic Diseases / blood,  etiology*,  physiopathology
Bone Density
Bone Diseases, Metabolic / blood,  complications*,  physiopathology
Calcinosis / blood,  etiology*,  physiopathology
Carrier Proteins / blood*
Female
Glycoproteins / blood
Humans
Lumbar Vertebrae / physiopathology
Membrane Glycoproteins / blood*
Osteoprotegerin
Premenopause
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Receptors, Cytoplasmic and Nuclear / blood
Receptors, Tumor Necrosis Factor / blood
Takayasu Arteritis / blood,  complications*,  physiopathology
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Glycoproteins; 0/Membrane Glycoproteins; 0/Osteoprotegerin; 0/RANK Ligand; 0/Receptor Activator of Nuclear Factor-kappa B; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF11A protein, human; 0/TNFRSF11B protein, human; 0/TNFSF11 protein, human

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