| Low blood flow at onset of moderate-intensity exercise does not limit muscle oxygen uptake. | |
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MedLine Citation:
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PMID: 20089709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 +/- 1 W, mean +/- SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (N(G)-monomethyl-l-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25-50% lower (P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O(2) difference) was higher (P < 0.05) in DB than in Con (5 s: 127 +/- 3 vs. 56 +/- 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P < 0.05) during exercise in DB than in Con (5 s: 59 +/- 12 vs. 262 +/- 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise. |
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Authors:
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Michael Nyberg; Stefan P Mortensen; Bengt Saltin; Ylva Hellsten; Jens Bangsbo |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-20 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 298 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R843-8 Citation Subset: IM |
Affiliation:
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The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cyclooxygenase Inhibitors / administration & dosage Drug Combinations Enzyme Inhibitors / administration & dosage Exercise / physiology* Femoral Artery / physiology Humans Indomethacin / administration & dosage* Leg / blood supply Male Muscle, Skeletal / physiology* Nitric Oxide / metabolism Nitroarginine / administration & dosage* Oxygen Consumption / drug effects, physiology* Peroxides / blood Prostaglandins / metabolism Regional Blood Flow / drug effects, physiology* Urea / analogs & derivatives, blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Drug Combinations; 0/Enzyme Inhibitors; 0/Peroxides; 0/Prostaglandins; 10102-43-9/Nitric Oxide; 124-43-6/carbamide peroxide; 2149-70-4/Nitroarginine; 53-86-1/Indomethacin; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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