Document Detail

Low birthweight in schizophrenia: prematurity or poor fetal growth?
MedLine Citation:
PMID:  11278135     Owner:  NLM     Status:  MEDLINE    
In the general population, low birthweight (LBW) is associated with neurological and psychological problems during childhood and adolescence. LBW may result from premature birth or poor fetal growth, and the independent effects of these two events on childhood development are not fully understood. The rate of low weight births is increased in schizophrenia and is associated with social withdrawal during childhood and an early onset of illness. However, it is unclear whether this LBW reflects poor fetal growth or premature birth, or whether these two risk factors have distinct implications for childhood functioning and age at onset of schizophrenia. Subjects included 270 patients with schizophrenia for whom a detailed history of obstetric events could be obtained. The rate of low weight births was high and was associated with poorer premorbid functioning and an earlier age at illness onset. The rate of both premature births and poor fetal growth was high relative to the normal population. Prematurity, but not poor fetal growth, was associated with premorbid social withdrawal and an early age at illness onset. Poor fetal growth, but not prematurity, was associated with low educational achievement. These results suggest that poor fetal growth and prematurity are associated with distinct patterns of childhood maladjustment in individuals who develop schizophrenia.
G N Smith; S W Flynn; N McCarthy; B Meistrich; T S Ehmann; G W MacEwan; S Altman; L C Kopala; W G Honer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  47     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-06-28     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  177-84     Citation Subset:  IM    
Department of Psychiatry, University of British Columbia, Vancouver Hospital Research Pavilion, 828 West 10th Avenue, BC V5Z 1L8, Vancouver, BC, V5Z 1L8, Canada.
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MeSH Terms
Age of Onset
Embryonic and Fetal Development / physiology*
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Middle Aged
Schizophrenia / epidemiology*
Social Alienation / psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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