Document Detail


Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth.
MedLine Citation:
PMID:  17030683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It remains unclear whether the association between low birth weight and insulin resistance in adulthood has its origin in utero or whether it develops later in life depending on predisposition and exogenous factors. METHODS AND RESULTS: Total glycosylated hemoglobin (TGH) was quantified at delivery in 1295 mother/child pairs serving as a surrogate of maternal and fetal glycemia. Multivariable regression analysis considering gestational age at delivery, the child's sex, maternal body mass index, and smoking during pregnancy revealed that an increase in TGH by 1% in the child was significantly associated with a mean birth weight reduction of 135 g (P<0.0001), whereas the same increase in the mother was associated with a mean birth weight increase of 88 g (P<0.0001). The ratio of fetal/maternal TGH suggests that lighter newborns have a higher percentage of TGH than would be expected from maternal TGH. CONCLUSIONS: The study demonstrates for the first time in a large population that there is an inverse association between TGH of a newborn and its birth weight. This might be due to increased insulin resistance in newborns with lower birth weight. Our data suggest that the pathophysiological mechanisms linking prenatal growth and postnatal sensitivity to insulin are present as early as before birth.
Authors:
Thiemo Pfab; Torsten Slowinski; Michael Godes; Horst Halle; Friedrich Priem; Berthold Hocher
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-09
Journal Detail:
Title:  Circulation     Volume:  114     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-17     Completed Date:  2006-11-13     Revised Date:  2007-06-07    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1687-92     Citation Subset:  AIM; IM    
Affiliation:
Center for Cardiovascular Research/Institute of Pharmacology, Charité Mitte, 10115 Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight / physiology
Cardiovascular Diseases / blood*,  epidemiology,  etiology
Female
Hemoglobin A, Glycosylated / metabolism*
Humans
Infant, Low Birth Weight / blood*
Infant, Newborn
Parturition / blood
Pregnancy
Risk Factors
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated
Comments/Corrections
Comment In:
Circulation. 2007 May 15;115(19):e462; author reply e463-4   [PMID:  17502583 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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