| Low birth weight and preterm births: etiologic fraction attributable to prenatal drug exposure. | |
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MedLine Citation:
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PMID: 16107872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). STUDY DESIGN: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. RESULTS: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). CONCLUSION: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine. |
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Authors:
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Henrietta S Bada; Abhik Das; Charles R Bauer; Seetha Shankaran; Barry M Lester; Charlotte C Gard; Linda L Wright; Linda Lagasse; Rosemary Higgins |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 25 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-29 Completed Date: 2006-01-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 631-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, College of Medicine and College of Public Health, University of Kentucky, Lexington, KY 40536, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cocaine
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toxicity Dose-Response Relationship, Drug Female Fetal Growth Retardation / chemically induced, etiology Fetus / drug effects* Humans Infant, Low Birth Weight* Infant, Newborn Infant, Premature* Obstetric Labor, Premature / etiology Pregnancy Risk Factors Smoking / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-2-3159/HD/NICHD NIH HHS; U01 HD 36790/HD/NICHD NIH HHS; U10 HD 21385/HD/NICHD NIH HHS; U10 HD 21397/HD/NICHD NIH HHS; U10 HD 21415/HD/NICHD NIH HHS; U10 HD 27904/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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