Document Detail

Low birth weight is not associated with thyroid autoimmunity: a population-based twin study.
MedLine Citation:
PMID:  16822815     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Low birth weight has been proposed as a risk factor for the development of antibodies toward thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) in adult life. However, the association could also be due to genetic or environmental factors affecting both birth weight and the development of thyroid autoantibodies. The effect of these confounders can be minimized through investigation of twin pairs. OBJECTIVE AND DESIGN: To examine the impact of low birth weight on the development of thyroid autoimmunity, we studied whether within-twin-cohort and within-twin-pair differences in birth weight are associated with differences in the serum concentration of TPOAb and TgAb in adult life. PARTICIPANTS: We studied 1024 euthyroid twin individuals who were distributed in 512 same-sex twin pairs. METHODS: Original midwife protocols were traced manually through the Provincial Archives of Denmark. TPOAb and TgAb were measured using solid-phase time-resolved fluoroimmunometric assays. RESULTS: There were no statistically significant associations between birth weight and serum concentrations of TPOAb [regression coefficient (beta) = 0.003 (95% confidence interval, -0.010 to 0.015); P = 0.67] or TgAb [beta = 0.002 (-0.010 to 0.014); P = 0.77]. When restricting the analysis to twin pairs with a within-pair difference in birth weight of 500 g or greater or to twin pairs born 4 wk or more before term, the regression coefficients were almost unchanged. Controlling for potential confounders (sex, zygosity, gestational age, TSH, and smoking) did not change the findings of nonsignificant regression coefficients. CONCLUSION: Low birth weight per se has no evident role in the etiology of thyroid autoimmunity.
Thomas Heiberg Brix; Pia Skov Hansen; Annette Beck Rudbeck; Jacob Bjerg Hansen; Axel Skytthe; Kirsten Ohm Kyvik; Laszlo Hegedüs
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Publication Detail:
Type:  Journal Article; Twin Study     Date:  2006-07-05
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  91     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2006-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3499-502     Citation Subset:  AIM; IM    
Department of Endocrinology and Metabolism, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
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MeSH Terms
Autoantibodies / blood
Autoimmunity / genetics,  immunology*
Diseases in Twins*
Infant, Low Birth Weight / immunology*
Infant, Newborn
Iodide Peroxidase / blood
Middle Aged
Regression Analysis
Thyroid Diseases / blood,  genetics,  immunology*
Thyrotropin / blood
Twins, Dizygotic
Twins, Monozygotic
Reg. No./Substance:
0/Autoantibodies; 0/anti-thyroglobulin; 9002-71-5/Thyrotropin; EC Peroxidase

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