| Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age. | |
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MedLine Citation:
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PMID: 19737922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most children born small for gestational age (SGA) normalize their body size by late infancy. Between 2 and 6 yr, such SGA children develop higher circulating levels of insulin, lower levels of adiponectin, and more visceral fat than appropriate-for-gestational-age (AGA) controls, even in the absence of overweight. Here we report on their further course between 6 and 8 yr. STUDY DESIGN AND POPULATION: Longitudinal study over 2 yr comparing data from 32 AGA vs. 32 SGA children, matched for gender, height, weight, and body mass index at the age of 6 yr. MAIN OUTCOMES: Fasting insulin, dehydroepiandrosterone sulfate (DHEAS), SHBG, high-molecular-weight (HMW) adiponectin, leptin, IGF-I; body composition by absorptiometry; and abdominal fat partitioning by magnetic resonance imaging. RESULTS: Between 6 and 8 yr, novel AGA-vs.-SGA divergences emerged (higher DHEAS and lower SHBG in SGA; P < 0.001), and some earlier divergences widened further (HMW adiponectin, visceral fat; P < 0.001), whereas others stabilized (fasting insulin, IGF-I). At age 8 yr, the most discerning features of SGA children were a high ratio of visceral over sc fat in the abdominal region (69% of SGA children), HMW hypoadiponectinemia (41%), fasting hyperinsulinemia (34%), and elevated circulating IGF-I levels (31%). CONCLUSION: SGA children with spontaneous catch-up growth develop relatively high DHEAS and low SHBG levels and become more often HMW hypoadiponectinemic and viscerally adipose between 6 and 8 yr of age. |
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Authors:
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Lourdes Ibáñez; Abel Lopez-Bermejo; Marta Díaz; Larisa Suárez; Francis de Zegher |
Publication Detail:
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Type: Journal Article Date: 2009-09-08 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 94 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-07 Completed Date: 2009-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3696-9 Citation Subset: AIM; IM |
Affiliation:
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Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, 08950 Esplugues, Barcelona, Spain. libanez@hsjdbcn.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adiponectin / deficiency* Age Factors Biological Markers / blood Body Composition* Body Mass Index Case-Control Studies Child Dehydroepiandrosterone Sulfate / blood* Female Humans Infant, Low Birth Weight* Infant, Newborn Infant, Small for Gestational Age* Insulin-Like Growth Factor I / metabolism Intra-Abdominal Fat / metabolism* Leptin / blood Longitudinal Studies Magnetic Resonance Imaging Male Sex Hormone-Binding Globulin / deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers; 0/Leptin; 0/Sex Hormone-Binding Globulin; 651-48-9/Dehydroepiandrosterone Sulfate; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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