Document Detail


Low-amplitude propagated contractile waves: a relevant propulsive mechanism of human colon.
MedLine Citation:
PMID:  11303973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Human colonic motility is still poorly understood, especially as far as concerns its propulsive function. Available data refer almost exclusively to the forceful propulsive activity, which is recognized as high-amplitude propagated contractions, the manometric equivalent of mass movements. By contrast, information on less vigorous propulsive contractions is still lacking. AIMS: To investigate the presence and behaviour of low-amplitude propagated contractile waves (less than 50 mmHg in amplitude) in the colon of healthy humans during a 24-hour study period. SUBJECTS AND METHODS: A series of 16 healthy volunteers of both sexes entered the study, and were investigated by a standard technique involving a colonoscopically-positioned manometric catheter. During the study, two standard 1,000 kcal mixed meal and a 450 kcal breakfast were served. The recordings were, therefore, scanned for the presence of low-amplitude propagated contractile waves (waves of less than 50 mmHg in amplitude, propagated over at least three consecutive recording ports), their daily distribution, and their relationship with physiological events. RESULTS: Low-amplitude propagated contractile waves were constantly present in all the tracings, with an average of about 61 events/subject/day and a mean amplitude of about 20 mmHg. More than 80% of these events appeared during the day, with a significant (p<0.05) increase after meals and after morning awakening. In 25% of subjects, these waves were accompanied by emission of flatus. CONCLUSIONS: In the human colon, low-amplitude propagated contractile waves are a constant physiological propulsive pattern, which is generally related to sleep-wake cycles and meal ingestion.
Authors:
G Bassotti; M Clementi; E Antonelli; M A Pelli; M Tonini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  33     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  36-40     Citation Subset:  IM    
Affiliation:
Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy. gabassot@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Circadian Rhythm / physiology
Colon / physiology*
Electrodes
Female
Gastrointestinal Motility / physiology*
Humans
Male
Manometry / instrumentation
Middle Aged
Postprandial Period / physiology
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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