Document Detail


Low alfentanil target-concentrations improve hemodynamic and intubating conditions during induction with sevoflurane.
MedLine Citation:
PMID:  15064269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the effects of different alfentanil target-concentrations on hemodynamics, respiration and conditions of tracheal intubation during an inhalation induction with 8% sevoflurane. METHODS: In this prospective randomized open-label study, 40 ASA I adult patients received alfentanil at the following target-concentrations: zero (Group 0), 25 (Group 25), 50 (Group 50) and 75 ng*mL(-1) (Group 75), starting five minutes before induction of anesthesia with 8% sevoflurane in 50% nitrous oxide. The ease of intubation was determined on fixed criteria and scored; arterial pressure, heart rate and bispectral index (BIS) were recorded at one-minute intervals. RESULTS: Times to allow tracheal intubation were shortened only in Group 75 (94 +/- 8 sec) as compared to Group 0 (140 +/- 11 sec, P < 0.05). BIS values, tracheal intubation scores and number of attempts were not different between groups. However, more patients suffered from apnea in Group 75. Heart rate and mean arterial pressure remained stable in Group 75 whereas they increased significantly in the three other groups. No patient suffered hypotension. CONCLUSION: Adding alfentanil at a 75 ng*mL(-1) target-concentration during an inhalation induction with 8% sevoflurane in 50% nitrous oxide allows intubation slightly earlier and provides stable hemodynamic conditions but the incidence of apnea during induction is higher. Lower concentrations are of little clinical interest.
Authors:
Nathalie Nathan; David Vandroux; Mohammed Benrhaiem; Pierre Marquet; Pierre-Marie Preux; Pierre Feiss
Related Documents :
23933639 - Airway pressure release ventilation: improving oxygenation: indications, rationale, and...
24666419 - Bilevel positive airway pressure for obstructive sleep apnea.
8140869 - Effects of propofol on the human heart electrical system: a transesophageal pacing elec...
18062519 - Attenuation of hypotension using phenylephrine during induction of anaesthesia with pro...
24858149 - Comparison of efficacy of labetalol and fentanyl for attenuating reflex responses to la...
10866899 - Nitrous oxide prevents movement during orotracheal intubation without affecting bis value.
25314839 - Intraocular pressure in captive american flamingos (phoenicopterus ruber) as measured b...
24200249 - The effects of short-term relaxation therapy on indices of heart rate variability and b...
21434999 - Repeatability, reproducibility, and effect of head position on central venous pressure ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  51     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, CHU Dupuytren, Limoges, France. nathan@unilim.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alfentanil / administration & dosage,  pharmacology*
Analgesics, Opioid / administration & dosage,  pharmacology
Analysis of Variance
Anesthetics, Inhalation / therapeutic use
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Electroencephalography
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Intubation, Intratracheal / methods*
Methyl Ethers / therapeutic use*
Prospective Studies
Reflex / drug effects
Time Factors
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Trendelenburg position, head elevation and a midline position optimize right internal jugular vein d...
Next Document:  Ophthalmic artery blood flow velocity increases during hypocapnia.