Document Detail

Low alfentanil target-concentrations improve hemodynamic and intubating conditions during induction with sevoflurane.
MedLine Citation:
PMID:  15064269     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effects of different alfentanil target-concentrations on hemodynamics, respiration and conditions of tracheal intubation during an inhalation induction with 8% sevoflurane. METHODS: In this prospective randomized open-label study, 40 ASA I adult patients received alfentanil at the following target-concentrations: zero (Group 0), 25 (Group 25), 50 (Group 50) and 75 ng*mL(-1) (Group 75), starting five minutes before induction of anesthesia with 8% sevoflurane in 50% nitrous oxide. The ease of intubation was determined on fixed criteria and scored; arterial pressure, heart rate and bispectral index (BIS) were recorded at one-minute intervals. RESULTS: Times to allow tracheal intubation were shortened only in Group 75 (94 +/- 8 sec) as compared to Group 0 (140 +/- 11 sec, P < 0.05). BIS values, tracheal intubation scores and number of attempts were not different between groups. However, more patients suffered from apnea in Group 75. Heart rate and mean arterial pressure remained stable in Group 75 whereas they increased significantly in the three other groups. No patient suffered hypotension. CONCLUSION: Adding alfentanil at a 75 ng*mL(-1) target-concentration during an inhalation induction with 8% sevoflurane in 50% nitrous oxide allows intubation slightly earlier and provides stable hemodynamic conditions but the incidence of apnea during induction is higher. Lower concentrations are of little clinical interest.
Nathalie Nathan; David Vandroux; Mohammed Benrhaiem; Pierre Marquet; Pierre-Marie Preux; Pierre Feiss
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  51     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
Department of Anesthesia, CHU Dupuytren, Limoges, France.
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MeSH Terms
Alfentanil / administration & dosage,  pharmacology*
Analgesics, Opioid / administration & dosage,  pharmacology
Analysis of Variance
Anesthetics, Inhalation / therapeutic use
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hemodynamics / drug effects*
Intubation, Intratracheal / methods*
Methyl Ethers / therapeutic use*
Prospective Studies
Reflex / drug effects
Time Factors
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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