| Low affinity heparin is an antithrombotic agent. | |
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MedLine Citation:
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PMID: 8191399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the antithrombotic activities and haemorrhagic side effects of a low affinity heparin (LAH). In the rabbit thrombosis model using activated human serum as the thrombogenic challenge, the effect of LAH on 10' and 20' stasis was studied. At 10' stasis, 150 micrograms/kg of LAH reduced thrombus formation by 67% and total prevention was achieved at 500 micrograms/kg. At 20' stasis, 150 micrograms/kg was totally ineffective, 500 micrograms/kg was partially effective and 1000 micrograms/kg was required to achieve complete prevention of thrombosis. Mean peak circulatory level following infusion of 500 micrograms/kg of LAH was found to be 1.6 micrograms/ml by heparin cofactor II based assay and 0.13 iu/ml by anti-factor Xa assay. Thrombin generation tests of the same post injection samples showed an 80% reduction in thrombin production when compared with pre-injection samples. At 2.5 mg/kg, the mean bleeding time ratio (challenge:control) measured in the rabbit ear template model was 1.25 (cf saline control 0.88). Compared with results from previous studies on unfractionated heparin and dermatan sulphate, LAH is approximately 6 times less effective than UFH but 5 times more potent than dermatan sulphate. Since the mean bleeding time for UFH at 2.5 mg/kg was previously found to increase nearly two fold over the control value, LAH may present a lesser haemorrhagic risk than UFH. These data suggest that LAH is more effective in directly preventing venous thrombosis than dermatan sulphate. Although LAH is not as effective as UFH on a weight basis in the impairment of thrombogenesis, it may carry significantly lower bleeding risk. |
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Authors:
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E Gray; S Cesmeli; J C Lormeau; A B Davies; D A Lane |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 71 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-06-23 Completed Date: 1994-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY |
Other Details:
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Languages: eng Pagination: 203-7 Citation Subset: IM |
Affiliation:
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National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bleeding Time Dermatan Sulfate / pharmacology, toxicity Disease Models, Animal Hemorrhage / chemically induced Heparin / blood, pharmacology*, toxicity Humans Metabolic Clearance Rate Rabbits Thrombin / biosynthesis Thrombophlebitis / prevention & control* |
| Chemical | |
Reg. No./Substance:
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24967-94-0/Dermatan Sulfate; 9005-49-6/Heparin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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