Document Detail


Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses.
MedLine Citation:
PMID:  23169669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lung is an important entry site for pathogens; its exposure to antigens results in systemic as well as local IgA and IgG antibodies. Here we show that intranasal administration of virus-like particles (VLPs) results in splenic B-cell responses with strong local germinal-center formation. Surprisingly, VLPs were not transported from the lung to the spleen in a free form but by B cells. The interaction between VLPs and B cells was initiated in the lung and occurred independently of complement receptor 2 and Fcγ receptors, but was dependent upon B-cell receptors. Thus, B cells passing through the lungs bind VLPs via their B-cell receptors and deliver them to local B cells within the splenic B-cell follicle. This process is fundamentally different from delivery of blood or lymph borne particulate antigens, which are transported into B cell follicles by binding to complement receptors on B cells.
Authors:
Juliana Bessa; Franziska Zabel; Alexander Link; Andrea Jegerlehner; Heather J Hinton; Nicole Schmitz; Monika Bauer; Thomas M Kündig; Philippe Saudan; Martin F Bachmann
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Publication Detail:
Type:  Journal Article     Date:  2012-11-20
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  2013-02-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20566-71     Citation Subset:  IM    
Affiliation:
Research Department, Cytos Biotechnology, CH-8952 Zurich-Schlieren, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Adoptive Transfer
Animals
Antibodies, Viral / biosynthesis
Antigens, Viral / administration & dosage,  blood
B-Lymphocytes / immunology*,  virology*
Cell Movement / immunology
Female
Immunoglobulin G / biosynthesis
Lung / immunology,  virology
Mice
Mice, Inbred C57BL
Receptors, Antigen, B-Cell / immunology
Receptors, Complement 3d / immunology
Receptors, IgG / immunology
Spleen / immunology,  virology
Vaccines, Virus-Like Particle / administration & dosage,  blood,  immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Fcgr2b protein, mouse; 0/Immunoglobulin G; 0/Receptors, Antigen, B-Cell; 0/Receptors, Complement 3d; 0/Receptors, IgG; 0/Vaccines, Virus-Like Particle
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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