| Low admission LDL-cholesterol is associated with increased 3-year all-cause mortality in patients with non ST segment elevation myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 19437396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The relationship between admission low-density lipoprotein (LDL) levels and long-term outcomes has not been established in patients with acute coronary syndrome. We tested the hypothesis that patients who develop non-ST segment elevation myocardial infarction (NSTEMI) despite low LDL have a worse cardiovascular outcome in the long term. METHODS: Patients admitted with NSTEMI between 1 January 1997 and 31 December 2000 and with fasting lipid profiles measured within 24 hours of admission were selected for analysis. Baseline characteristics and 3-year all-cause mortality were compared between the patients with LDL above and below the median. Multivariate analysis was used to determine the predictors of all-cause mortality, and adjusted survival was analyzed using the Cox proportional hazard model. RESULTS: Of the total of 517 patients, 264 had LDL <or= 105 mg/dL and 253 had LDL > 105 mg/dL. There was no difference in age, gender, severity of coronary artery disease, and left ventricular ejection fraction between the 2 groups. Thirty-six percent of patients with LDL <or= 105 mg/dL and 24% of patients with LDL > 105 mg/dL were on lipid-lowering therapy on admission. After 3 years, patients with admission LDL <or= 105 mg/dL had higher all-cause mortality rate compared to patients with LDL > 105 mg/dL (14.8% vs. 7.1%, p = 0.005). The higher all-cause mortality persisted (OR 1.8, 95% CI 1.0-3.5, p = 0.05) even after adjustment for confounding variables. CONCLUSIONS: In our cohort, lower LDL-cholesterol at admission was associated with decreased 3-year survival in patients with NSTEMI. Whether this was a result of current therapy or a marker for worse baseline characteristics needs to be studied further. |
| | |
Authors:
|
Mouaz H Al-Mallah; Hazem Hatahet; João L Cavalcante; Sanjaya Khanal |
Related Documents
:
|
21718356 - The effect of different atrioventricular delays on left atrium and left atrial appendag... 21737296 - Myocardial metabolism and diastolic function after aortic valve replacement for aortic ... 21757406 - Cognitive, biochemical, and imaging profile of patients suffering from idiopathic norma... 22327696 - Shunt-dependent hydrocephalus following subarachnoid hemorrhage correlates with increas... 21718356 - The effect of different atrioventricular delays on left atrium and left atrial appendag... 23588536 - Standard pentostatin dose reductions in renal insufficiency are not adequate: selected ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiology journal Volume: 16 ISSN: 1897-5593 ISO Abbreviation: - Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-05-13 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101392712 Medline TA: Cardiol J Country: Poland |
Other Details:
|
Languages: eng Pagination: 227-33 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Henry Ford Heart and Vascular Institute, Detroit, MI 48202, USA. malmall1@hfhs.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biological Markers / blood Cholesterol, LDL / blood* Down-Regulation Female Humans Kaplan-Meiers Estimate Male Middle Aged Myocardial Infarction / blood*, mortality*, therapy Odds Ratio Patient Admission* Proportional Hazards Models Registries Retrospective Studies Risk Assessment Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Cholesterol, LDL |
| Comments/Corrections | |
Comment In:
|
Cardiol J. 2009;16(3):195-6
[PMID:
19437392
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk factors of supraventricular arrhythmia in adults with congenital heart disease.
Next Document: Clinical outcome of patients with diabetes presenting with ST-elevation myocardial infarction and tr...