| Low adiponectin levels predict late in-stent restenosis after bare metal stenting in native coronary arteries. | |
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MedLine Citation:
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PMID: 18180052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adiponectin, the most abundant protein secreted from adipose tissue, possesses anti-atherogenic properties. This study tested whether adiponectin plasma levels predict in-stent restenosis (ISR) after successful percutaneous coronary intervention (PCI) with bare-metal stents. METHODS: The study included 148 consecutive patients who had elective PCI with bare-metal stents in de novo lesions of native coronary arteries for symptomatic coronary artery disease. Adiponectin levels were measured by ELISA 3 days or less before PCI. RESULTS: Angiographic ISR (defined as >50% diameter stenosis) was found in 49 (33%) patients during 6 months of the follow-up. Adiponectin levels were lower in patients with ISR than those without ISR (3.5+/-0.3 vs. 6.9+/-0.4 microg/ml, respectively, p<0.01). Adiponectin levels were inversely correlated with late luminal loss of the stented lesions (r=-0.40, p<0.01). Using multivariate logistic regression analysis, low adiponectin levels (<4.5 microg/ml, arbitrarily determined from a receiver operating characteristic curve) served as a predictor of ISR that was independent of angiographic and procedural variables, and clinical factors known to be associated with ISR (odds ratio, 7.9; 95% CI, 3.0-21; p<0.01). Furthermore, low adiponectin levels also independently predicted target lesion revascularization (n=35) during follow-up (odds ratio, 3.7; 95% CI, 1.4-9.7; p<0.01). CONCLUSIONS: Low adiponectin levels have a predictive value for late ISR after PCI with bare-metal stents in native coronary arteries. |
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Authors:
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Yoshinobu Kitta; Hajime Takano; Takamitsu Nakamura; Yasushi Kodama; Ken Umetani; Daisuke Fujioka; Yukio Saito; Ken-Ichi Kawabata; Jyun-Ei Obata; Akira Mende; Tsuyoshi Kobayashi; Kiyotaka Kugiyama |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-04 |
Journal Detail:
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Title: International journal of cardiology Volume: 131 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-28 Completed Date: 2009-08-27 Revised Date: 2010-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 78-82 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine II, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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biosynthesis,
blood* Aged Biological Markers / blood Coronary Restenosis / blood*, diagnosis, etiology* Coronary Vessels / metabolism*, physiopathology, surgery* Female Follow-Up Studies Humans Male Middle Aged Predictive Value of Tests Prospective Studies Stents* / adverse effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2010 Oct 8;144(2):236; author reply 237-8
[PMID:
19189874
]
Int J Cardiol. 2010 Nov 19;145(2):351 [PMID: 20045207 ] Int J Cardiol. 2009 Sep 11;137(1):54-5; author reply 56 [PMID: 18653252 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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