Document Detail

Low adiponectin levels predict late in-stent restenosis after bare metal stenting in native coronary arteries.
MedLine Citation:
PMID:  18180052     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adiponectin, the most abundant protein secreted from adipose tissue, possesses anti-atherogenic properties. This study tested whether adiponectin plasma levels predict in-stent restenosis (ISR) after successful percutaneous coronary intervention (PCI) with bare-metal stents.
METHODS: The study included 148 consecutive patients who had elective PCI with bare-metal stents in de novo lesions of native coronary arteries for symptomatic coronary artery disease. Adiponectin levels were measured by ELISA 3 days or less before PCI.
RESULTS: Angiographic ISR (defined as >50% diameter stenosis) was found in 49 (33%) patients during 6 months of the follow-up. Adiponectin levels were lower in patients with ISR than those without ISR (3.5+/-0.3 vs. 6.9+/-0.4 microg/ml, respectively, p<0.01). Adiponectin levels were inversely correlated with late luminal loss of the stented lesions (r=-0.40, p<0.01). Using multivariate logistic regression analysis, low adiponectin levels (<4.5 microg/ml, arbitrarily determined from a receiver operating characteristic curve) served as a predictor of ISR that was independent of angiographic and procedural variables, and clinical factors known to be associated with ISR (odds ratio, 7.9; 95% CI, 3.0-21; p<0.01). Furthermore, low adiponectin levels also independently predicted target lesion revascularization (n=35) during follow-up (odds ratio, 3.7; 95% CI, 1.4-9.7; p<0.01).
CONCLUSIONS: Low adiponectin levels have a predictive value for late ISR after PCI with bare-metal stents in native coronary arteries.
Yoshinobu Kitta; Hajime Takano; Takamitsu Nakamura; Yasushi Kodama; Ken Umetani; Daisuke Fujioka; Yukio Saito; Ken-Ichi Kawabata; Jyun-Ei Obata; Akira Mende; Tsuyoshi Kobayashi; Kiyotaka Kugiyama
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-04
Journal Detail:
Title:  International journal of cardiology     Volume:  131     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-08-27     Revised Date:  2010-12-21    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  IM    
Department of Internal Medicine II, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
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MeSH Terms
Adiponectin / biosynthesis,  blood*
Biological Markers / blood
Coronary Restenosis / blood*,  diagnosis,  etiology*
Coronary Vessels / metabolism*,  physiopathology,  surgery*
Follow-Up Studies
Middle Aged
Predictive Value of Tests
Prospective Studies
Stents* / adverse effects
Time Factors
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers
Comment In:
Int J Cardiol. 2010 Oct 8;144(2):236; author reply 237-8   [PMID:  19189874 ]
Int J Cardiol. 2010 Nov 19;145(2):351   [PMID:  20045207 ]
Int J Cardiol. 2009 Sep 11;137(1):54-5; author reply 56   [PMID:  18653252 ]

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