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Low absolute neutrophil counts in african infants.
MedLine Citation:
PMID:  16867975     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Infants of African origin have a lower normal range of absolute neutrophil counts than white infants; this fact, however, remains under appreciated by clinical researchers in the United States. During the initial stages of a clinical trial in Malawi, the authors noted an unexpectedly high number of infants with absolute neutrophil counts that would be classifiable as neutropenic using the National Institutes of Health's Division of AIDS toxicity tables. The authors argue that the relevant Division of AIDS table does not take into account the available evidence of low absolute neutrophil counts in African infants and that a systematic collection of data from many African settings might help establish the absolute neutrophil count cutpoints to be used for defining neutropenia in African populations.
Authors:
Athena P Kourtis; Brian Bramson; Charles van der Horst; Peter Kazembe; Yusuf Ahmed; Charles Chasela; Mina Hosseinipour; Rodney Knight; Lebah Lugalia; Gerald Tegha; George Joaki; Robert Jafali; Denise J Jamieson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)     Volume:  4     ISSN:  1545-1097     ISO Abbreviation:  J Int Assoc Physicians AIDS Care (Chic)     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2006-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185740     Medline TA:  J Int Assoc Physicians AIDS Care (Chic)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Affiliation:
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, apk3@cdc.gov.
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