Document Detail


Low-voltage aEEG as predictor of intracranial hemorrhage in preterm infants.
MedLine Citation:
PMID:  21481745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objectives of this prospective cohort study were to identify amplitude-integrated electroencephalography (aEEG) background patterns predictive of severe intracranial hemorrhage. Thirty ventilated preterm newborns weighing <1,000 g were assessed by an aEEG cerebral function monitor and ultrasound measurement of cerebral blood flow velocity at time of surfactant administration and tracheal suctioning simultaneously during first 48 hours of life. Birth weight was 624 ± 200 g (mean ± S.D.) and gestational age was 25 ± 2 weeks. Background electrical activity was predominantly discontinuous in 72% of infants. A sharp increase in electrical activity/burst density was observed during surfactant administration and tracheal suctioning in most infants, with a 33.5% increase in mean cerebral blood flow velocity. Burst suppression with low voltage was identified in 57% infants with severe intracranial hemorrhage, whereas no infant without hemorrhage exhibited this pattern (P = 0.014). We conclude that aEEG low-voltage burst suppression might have useful clinical applications with 100% positive predictive value for severe intracranial hemorrhage.
Authors:
Lina F Chalak; Natalie C Sikes; Melanie J Mason; Jeffrey R Kaiser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric neurology     Volume:  44     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-08-04     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity
Cohort Studies
Electroencephalography / methods*
Female
Humans
Infant, Newborn
Intracranial Hemorrhages / diagnosis*,  etiology*,  ultrasonography
Male
Middle Cerebral Artery / physiopathology
Predictive Value of Tests
Premature Birth / physiopathology*,  ultrasonography
Ultrasonography, Doppler, Transcranial / methods
Grant Support
ID/Acronym/Agency:
1 K23 NS43185/NS/NINDS NIH HHS; 1 R01 NS060674/NS/NINDS NIH HHS; 1UL1RR029884/RR/NCRR NIH HHS; KL2RR024983/RR/NCRR NIH HHS; RR20146/RR/NCRR NIH HHS; UL1 RR024982/RR/NCRR NIH HHS; UL1 RR024982/RR/NCRR NIH HHS; UL1 RR024982-04/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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