Document Detail


Low T8 antigen density on lymphocytes in active multiple sclerosis.
MedLine Citation:
PMID:  6236742     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The median fluorescence intensity of peripheral blood T8+ (T-suppressor/cytotoxic) cells in patients with active (relapsing or progressive) or stable multiple sclerosis (MS) and in control subjects was determined with a fluorescence-activated cell sorter using an indirect immunofluorescence assay. Median fluorescence intensity was significantly lower in patients with active MS than in controls. No differences in median fluorescence intensity were found between patients with stable MS and controls. Analysis of T8+ cells that had been modulated in vitro with OKT8 indicated that the resultant reduction in the median T8 antigen density per cell resulted in fewer T8+ cells being enumerated when the fluorescence-activated cell sorter was used than when a fluorescence microscope was used. Reduced median T8 antigen density on cells as found in active MS may contribute to the apparent underrepresentation of circulating T-suppressor cells in such patients and may be associated with reduced suppressor cell function.
Authors:
A T Reder; J P Antel; J J Oger; T A McFarland; M Rosenkoetter; B G Arnason
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  16     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-10-25     Completed Date:  1984-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / analysis
Antigens / analysis
Antigens, CD3
Antigens, Surface / analysis*
Fluorescent Antibody Technique
Humans
Leukocyte Count
Multiple Sclerosis / immunology*
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Regulatory / immunology*
Grant Support
ID/Acronym/Agency:
2 T32 NS-07113/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens; 0/Antigens, CD3; 0/Antigens, Surface

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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