Document Detail


Low RIN1 Expression in HCC Is Associated With Tumor Invasion and Unfavorable Prognosis.
MedLine Citation:
PMID:  23765536     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objectives: To explore the association between the expression of Ras and Rab interactor 1 (RIN1) and the prognosis of hepatocellular carcinoma (HCC). Methods: RIN1 expression was detected in paired HCC tissues by real-time polymerase chain reaction, Western blot analysis, and immunohistochemistry. Transfection was applied to analyze the RIN1 function. Results: We found that expression of the RIN1 protein was downregulated in the HCC samples compared with the corresponding normal tissues. Downregulation of RIN1 expression was also associated with invasion and poor overall survival (OS). The results of our multivariate analysis indicated that the RIN1 status is a significant prognostic factor for OS. RIN1 overexpression also inhibited cell invasion in HepG2 cells. The expression between RIN1 and ABL2 may present a positive correlation. Conclusions: Our results demonstrate that RIN1 suppresses tumor invasion in HCC patients and that a poor prognosis for HCC is expected when RIN1 expression is downregulated.
Authors:
Hui He; Gang Wu; Haiyang Liu; Ying Cheng; Yanqiu Yu; Yawei Wang; Yongfeng Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  140     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-81     Citation Subset:  AIM; IM    
Affiliation:
Dept. of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110001 Liaoning, China; yfliu@mail.cmu.edu.cn.
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