| Low Plasma Level of Atrial Natriuretic Peptide Predicts Development of Diabetes: The Prospective Malmo Diet and Cancer Study. | |
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MedLine Citation:
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PMID: 22112816 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:The cardiac natriuretic peptides are involved in blood pressure regulation, and large cross-sectional studies have shown lower plasma levels of N-terminal pro-natriuretic peptide levels [N-terminal atrial natriuretic peptide (N-ANP) and N-terminal brain natriuretic peptide (N-BNP)] in patients with insulin resistance, obesity, and diabetes.Objective:In this study, we prospectively tested whether plasma levels of mid-regional ANP (MR-ANP) and N-BNP predict new-onset diabetes and long-term glucose progression.Design, Setting, and Patients:MR-ANP and N-BNP were measured in 1828 nondiabetic individuals of the Malmö Diet and Cancer cohort (mean age 60 yr; 61% women) who subsequently underwent a follow-up exam including an oral glucose tolerance test after a median follow-up time of 16 yr. Logistic regression was used to adjust for covariates.Results:During follow-up, 301 subjects developed new-onset diabetes. After full multivariate adjustment, MR-ANP was significantly inversely associated with incident diabetes (OR = 0.85; 95% CI = 0.73-0.99; P = 0.034) but not N-BNP (OR = 0.92; 95% CI = 0.80-1.06; P = 0.262). In fully adjusted linear regression models, the progression of fasting glucose during follow-up was significantly inversely related to baseline levels of MR-ANP (P = 0.004) but not N-BNP (P = 0.129). Quartile analyses revealed that the overall association was mainly accounted for by excess risk of incident diabetes in subjects belonging to the lowest quartile of MR-ANP. After full adjustment, the odds ratio for incident diabetes in the bottom compared with the top quartile of MR-ANP was 1.65 (OR = 1.08-2.51, P = 0.019) and 1.43 (OR = 1.04-1.96, P = 0.027) compared with all other subjects.Conclusion:Low plasma levels of MR-ANP predict development of future diabetes and glucose progression over time, suggesting a causal role of ANP deficiency in diabetes development. |
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Authors:
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Martin Magnusson; Amra Jujic; Bo Hedblad; Gunnar Engström; Margaretha Persson; Joachim Struck; Nils G Morgenthaler; Peter Nilsson; Christopher Newton-Cheh; Thomas J Wang; Olle Melander |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Clinical Sciences (M.M., B.H., G.E., M.P., P.N., O.M.) and Cardiology (M.M.) and Center of Emergency Medicine (B.H., P.N., O.M.), Lund University, Skåne University Hospital, and Department of Biomedical Laboratory Science (A.J.), Malmö University, SE-205 02 Malmö, Sweden; Cardiology Division (T.J.W., C.N.-C.), Center for Human Genetic Research (C.N.-C.), Cardiovascular Research Center (T.J.W., C.N.-C.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Program in Medical and Population Genetics (C.N.-C.), Broad Institute of Harvard and Massachusetts of Institute of Technology, Cambridge, Massachusetts 02142; and Thermo Fisher Scientific (J.S., N.G.M), 16761 Hennigsdorf, Germany. |
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