Document Detail


Low oxygen saturation target range is associated with increased incidence of intermittent hypoxemia.
MedLine Citation:
PMID:  22738947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the hypothesis that preterm infants randomized to a low vs high O(2) saturation target range have a higher incidence of intermittent hypoxemia.
STUDY DESIGN: A subcohort of 115 preterm infants with high resolution pulse oximetry enrolled in the Surfactant, Positive Pressure, and Oxygenation Randomized Trial were randomized to low (85%-89%) or high (91%-95%) O(2) saturation target ranges. Oxygen saturation was monitored until 36 weeks postmenstrual age or until the infant was breathing room air without respiratory support for ≥72 hours.
RESULTS: The low target O(2) saturation group had a higher rate of intermittent hypoxemia (≤80% for ≥10 seconds and ≤3 minutes) prior to 12 days and beyond 57 days of life (P < .05). The duration shortened (P < .0001) and the severity increased (P < .0001) with increasing postnatal age with no differences between target saturation groups. The higher rate of intermittent hypoxemia events in the low target group was associated with a time interval between events of <1 minute.
CONCLUSION: A low O(2) saturation target was associated with an increased rate of intermittent hypoxemia events that was dependent on postnatal age. The duration and severity of events was comparable between target groups. Further investigation is needed to assess the role of intermittent hypoxemia and their timing on neonatal morbidity.
Authors:
Juliann M Di Fiore; Michele Walsh; Lisa Wrage; Wade Rich; Neil Finer; Waldemar A Carlo; Richard J Martin;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-06-26
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-22     Completed Date:  2013-01-22     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1047-52     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA. jmd3@case.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Anoxia / blood,  epidemiology,  etiology*
Female
Humans
Incidence
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood,  epidemiology,  etiology*
Male
Models, Statistical
Monitoring, Physiologic
Oximetry
Oxygen / blood*
Prospective Studies
Regression Analysis
Respiration, Artificial / adverse effects*,  methods
Severity of Illness Index
Single-Blind Method
Grant Support
ID/Acronym/Agency:
HD021364-23/HD/NICHD NIH HHS; M01 RR32/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; U10 HD021364/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen
Investigator
Investigator/Affiliation:
Abhik Das / ; Marie Gantz / ; Alan H Jobe / ; Michael S Caplan / ; Avroy A Fanaroff / ; Nancy S Newman / ; Bonnie S Siner / ; Arlene Zadell / ; Rosemary D Higgins / ; Stephanie Wilson Archer / ; Abhik Das / ; W Kenneth Poole / ; Marie G Gantz / ; Margaret Cunningham / ; Betty K Hastings / ; Jeanette O'Donnell Auman / ; Carolyn Petrie Huitema / ; James W Pickett / ; Dennis Wallace / ; Kristin M Zaterka-Baxter / ; Monica V Collins / ; Shirley S Cosby / ; Vivien A Phillips / ; Maynard R Rasmussen / ; Paul R Wozniak / ; Kathy Arnell / ; Renee Bridge / ; Clarence Demetrio /
Comments/Corrections

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