| Low Maternal Middle Cerebral Artery Doppler Resistance Indices Can Predict Future Development of Preeclampsia. | |
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MedLine Citation:
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PMID: 22173946 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AUTHORS: Michael Belfort, MBBCH, MD, PhD; Teelkien Van Veen; G. Lance White; ShaleceKofford, RN, MPH; Janalee Allred, RN; InekePostma; Michael Varner, MD OBJECTIVE: To determine if decreased resistance (vasodilatation) in the Maternal Middle Cerebral Artery (MMCA)in the second trimester can predict third trimester development of preeclampsia. STUDY DESIGN: 405 low risk gravidas had MMCA Transcranial Doppler (TCD) once in the second trimester. Maternal/neonatal outcomes were evaluated after delivery. Mean BP, MMCA velocities, Resistance Index (RI), Pulsatility Index (PI), and Cerebral Perfusion Pressure (CPP) were compared between normotensive and preeclamptic cohorts. RESULTS: Seven subjects (1.7%) developed preeclampsia. An RI <0.54 and PI <0.81 were clinically useful in predicting subsequent preeclampsia.Areas under the ROC curves for RI and PI were 0.93 and 0.93 respectively with optimal sensitivity and specificity of 86% and 93%. Positive and Negative Likelihood Ratios were 11.8/0.15 (RI), 12.3/0.15 (PI). CONCLUSIONS: TCD indices of low MMCA resistance in the second trimester are predictive of the subsequent development of preeclampsia in a low risk, ethnically homogenous population. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
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Authors:
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Michael Belfort; Teelkien Van Veen; G Lance White; Shalece Kofford; Janalee Allred; Ineke Postma; Michael Varner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Baylor College of Medicine, Houston, TX. belfort@bcm.edu. |
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