| Low Luminance Contrast Stimulation is Optimal for Early Detection of Glaucoma Using Multifocal Visual Evoked Potentials. | |
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MedLine Citation:
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PMID: 21296828 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: The Blue-on-Yellow multiocal visual evoked potential (BonY mfVEP) stimulus is more sensitive than the conventional black-white pattern reversal stimulus in identifying early glaucoma. BonY employs pattern-onset stimulation, and lower luminance contrast (40%) in addition to colour. This study aimed at elucidating the mechanism responsible for enhanced performance of the BonY stimulus. Methods: Multifocal pattern-onset VEPs were recorded in response to Blue --on-Yellow, high luminance contrast achromatic (HLA) and low luminance contrast achromatic (LLA) stimulations in 30 normals (to construct normative databases) and 23 patients with early glaucoma (MD < 6 dB). In addition, specificity of BonY and LLA stimulation was examined using a further subset of 25 normal subjects. Results: In normal subjects LLA mfVEP had significantly lower amplitudes as compared to BonY and HLA mfVEP (P<0.001), which were not significantly different from each other. In glaucomatous eyes, all three stimuli demonstrated significantly reduced amplitude in comparison to normal subjects. While sensitivities of both BonY and LLA in identifying subjective visual field defects were similarly high (93% and 89.7% respectively), HLA showed only 79.3% detection rate. BonY and LLA demonstrated significantly higher defect severity scores than HLA (p<0.05 for both). Specificities for BonY and LLA were similar (96 %). Conclusions: BonY and LLA mfVEPs performed comparably, and both did significantly better than HLA mfVEP in identifying early glaucoma. Enhanced performance of BonY stimulation is most likely due to its low-luminance contrast component rather than pattern-onset mode of presentation or its chromatic properties. |
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Authors:
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Hemamalini Arvind; Alexander Klistorner; John Grigg; Stuart L Graham |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-4 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The University of Sydney. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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