| Low Levels of Protein Z Are Associated With HELLP Syndrome and its Severity. | |
| | |
MedLine Citation:
|
PMID: 20460354 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Protein Z (PZ) was found to be associated with pregnancy complications. There are no data implying an association between hemolysis (H), elevated liver enzymes (EL), and low platelet counts (LP) (HELLP) syndrome and changes in plasma levels of PZ. The aim of this study is to investigate whether HELLP syndrome is associated with plasma concentrations of PZ. Protein Z levels in 29 women with HELLP syndrome were compared with 29 healthy, nulliparous and 25 normal pregnant women. The median PZ levels in patients with HELLP syndrome were found to be significantly lower than those of pregnant women. No significant difference was found between HELLP and healthy groups. Protein Z levels correlated with platelet counts, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) levels in patients with HELLP syndrome. Median PZ level was higher in partial HELLP than in complete HELLP. We calculated 1330 ng/mL as a cutoff value for PZ level to discriminate HELLP syndrome from normal pregnancy. Low PZ levels are associated with the pathobiology of HELLP syndrome. |
| | |
Authors:
|
Isik Kaygusuz; Tulin Firatli-Tuglular; Tayfur Toptas; Vedat Ugurel; Muzaffer Demir |
Related Documents
:
|
20101854 - Regional anaesthesia for primary caesarean section in patients with preterm hellp syndr... 17274584 - Mr diagnosis of transdural disc herniation causing cauda equine syndrome. 18774664 - Agranulocytosis following phenytoin-induced hypersensitivity syndrome. 10847654 - Hellp syndrome with haemaglobin vasospasm. 21584134 - Psychological aspects of irritable bowel syndrome. 17347054 - Landau-kleffner syndrome with lateral temporal focal cortical dysplasia and mesial temp... |
Publication Detail:
|
Type: Journal Article Date: 2010-05-11 |
Journal Detail:
|
Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 17 ISSN: 1938-2723 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
|
Languages: eng Pagination: 214-9 Citation Subset: IM |
Affiliation:
|
Division of Hematology, Department of Internal Medicine, Marmara University Hospital, Istanbul, Turkey. isikkaygusuz@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two New Mutations at ERGIC-53 Gene in a Turkish Family.
Next Document: Intensive Menstrual Bleeding Successfully Treated With Recombinant Factor VIIa in Glanzmann Thrombas...