Document Detail


Low-Intensity physical activity beneficially alters the ultrastructural renal morphology of spontaneously hypertensive rats.
MedLine Citation:
PMID:  21789392     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION AND OBJECTIVE: Kidney disorders can cause essential hypertension, which can subsequently cause renal disease. High blood pressure is also common among those with chronic kidney disease; moreover, it is a well-known risk factor for a more rapid progression to kidney failure. Because hypertension and kidney function are closely linked, the present study aimed to observe the beneficial effects of low-intensity physical activity on structural and ultrastructural renal morphology and blood pressure in normotensive and spontaneously hypertensive rats.
METHOD: Male Wistar-Kyoto rats and spontaneously hypertensive rats were randomly allocated into four groups: sedentary or exercised Wistar-Kyoto and sedentary or exercised spontaneously hypertensive rats. The exercise lasted 20 weeks and consisted of treadmill training for 1 hour/day, 5 days/week.
RESULTS: The exercised, spontaneously hypertensive rats showed a significant blood pressure reduction of 26%. The body masses of the Wistar-Kyoto and spontaneously hypertensive strains were significantly different. There were improvements in some of the renal structures of the animals treated with physical activity: (i) the interdigitations of the proximal and distal convoluted tubules; (ii) the basal membrane of the proximal and distal convoluted tubules; and (iii) in the basal membrane, slit diaphragm and pedicels of the glomerular filtration barrier. The spontaneously hypertensive rats also showed a decreased expression of connexin-43.
CONCLUSION: Physical exercise could be a therapeutic tool for improving kidney ultrastructure and, consequently, renal function in hypertensive individuals.
Authors:
Angélica Beatriz Garcia-Pinto; Verônica Soares de Matos; Vinicius Rocha; Jéssica Moraes-Teixeira; Jorge José Carvalho
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-26     Completed Date:  2012-06-08     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  855-63     Citation Subset:  IM    
Affiliation:
Histologia e Embriologia, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil. abpgarcia@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology*
Hypertension / physiopathology*,  rehabilitation
Immunohistochemistry
Kidney Glomerulus / physiopathology,  ultrastructure*
Kidney Tubules / physiopathology,  ultrastructure*
Male
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Physical Conditioning, Animal / physiology*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
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