Document Detail


Low Incidence of Asymptomatic Contrast-Enhancing Brain Lesions in Japanese Patients with Multiple Sclerosis.
MedLine Citation:
PMID:  21325853     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The number of contrast-enhancing brain lesions is used as an endpoint in multiple sclerosis (MS) clinical trials. However, the incidence of asymptomatic contrast-enhancing brain lesions (AEBLs) in Japanese patients with MS has not been determined. Objective: To describe the number of AEBLs per scan in Japanese patients with relapsing-remitting MS (RRMS). Methods: We reviewed the medical records of 23 Japanese patients with RRMS who showed (1) a stable or improving condition for at least 30 days before a magnetic resonance imaging (MRI) examination and (2) at least one relapse in the preceding year or two relapses in the preceding 2 years. Results: The percentage of patients with AEBLs was 39.1% (9/23 patients) and the number of AEBLs per scan was 0.37. Conclusions: The results suggest that the disease activity shown by brain MRI was lower in Japanese patients with MS compared with that in Caucasian patients.
Authors:
Masami Tanaka; Masaru Matsui; Masayuki Tahara; Keiko Tanaka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-12
Journal Detail:
Title:  European neurology     Volume:  65     ISSN:  1421-9913     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  119-122     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
MS Center, Utano National Hospital, Kyoto, Japan.
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