| Low immunohistochemical expression of MGMT in ACTH secreting pituitary tumors of patients with Nelson syndrome. | |
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MedLine Citation:
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PMID: 21061089 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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MGMT expression in tumors has been correlated with response to treatment with temozolomide therapy. Few medical therapies are available for Nelson syndrome, and the efficacy of such therapeutics remains limited. The aim of the present study was to assess immunohistochemical expression of MGMT in ACTH-secreting pituitary adenomas of patients with Nelson syndrome. Our material consisted of eight specimens from ACTH-secreting pituitary adenomas of patients with Nelson syndrome. Immunohistochemical staining for MGMT was performed using the streptavidin-biotin-peroxidase complex method. MGMT immunoreactivity was assessed microscopically and recorded as an estimated percentage of nuclear MGMT immunostaining (0 = none, 1=<10%, 2=<25%, 3=<50%, 4=>50%). Five of the eight specimens (65%) exhibited no MGMT immunoreactivity, with two out of eight cases (25%) showing slight MGMT staining (<10%) and one out of eight cases (12%) demonstrating moderate MGMT positivity (<25%). Patient male/female ratio was 3:5, with average patient age being 62.4 (range 57–66). Our findings suggest that temozolomide therapy may be of potential use in patients with Nelson syndrome, as these tumors express absent/low levels of MGMT. Absent or low MGMT staining in brain and other neoplasms has been shown to correlate with successful treatment with temozolomide, and recent reports of aggressive pituitary adenomas suggest similar outcomes. |
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Authors:
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Fateme Salehi; Bernd W Scheithauer; Veronica J Moyes; William M Drake; Luis V Syro; Branavan Manoranjan; Soniya Sharma; Eva Horvath; Kalman Kovacs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine pathology Volume: 21 ISSN: 1559-0097 ISO Abbreviation: Endocr. Pathol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 227-9 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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