| Low-grade albuminuria is associated with carotid intima-media thickness in Chinese type 2 diabetic patients. | |
| | |
MedLine Citation:
|
PMID: 20719840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Low-grade albuminuria was reported to be associated with cardiovascular risk factors. Our present study showed a significant association between low-grade urinary albumin-to-creatinine ratio (ACR) and elevated carotid intima-media thickness (CIMT) in type 2 diabetic patients. OBJECTIVE: The objective of this study is to evaluate the association between low-grade albuminuria and CIMT in type 2 diabetic patients. DESIGN, SETTING, PARTICIPANTS, AND MEASURES: A cross-sectional study was performed in 760 type 2 diabetic patients (age range, 29-76 yr) with normoalbuminuria from Shanghai, China. A first-voided early morning spot urine sample was obtained for urinary albumin and creatinine measurements. CIMT was measured using high-resolution B-mode ultrasonography. RESULTS: CIMT, as well as body mass index, glycated hemoglobin A1c, systolic and diastolic blood pressure, and serum triglycerides, progressively increased across the sex-specific quartiles of ACR (all P < 0.05). Compared with the patients in the lowest quartile, those in the third and the highest quartiles had significantly higher levels of CIMT (0.87 and 0.91 vs. 0.79 mm, P = 0.0025 and <0.0001, respectively). A fully adjusted logistic regression analysis revealed that compared with the patients in the lowest quartile of ACR, those in the third and the highest quartiles had 1.98- to 2.76-fold increased risk of elevated CIMT. CONCLUSIONS: In type 2 diabetic patients, slightly elevated ACR level, which was below the current cutoff point of microalbuminuria, was associated with higher CIMT after adjustments of conventional cardiovascular risk factors. The results implied that low-grade albuminuria might be an early marker for the detection of cardiovascular disease in type 2 diabetic patients. |
| | |
Authors:
|
Yun Huang; Yuhong Chen; Min Xu; Weiqiong Gu; Yufang Bi; Xiaoying Li; Guang Ning |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-18 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 5122-8 Citation Subset: AIM; IM |
Affiliation:
|
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Albuminuria / ultrasonography* Asian Continental Ancestry Group Cardiovascular Diseases / ultrasonography Carotid Arteries / ultrasonography* Chi-Square Distribution China Cross-Sectional Studies Diabetes Mellitus, Type 2 / ultrasonography* Female Humans Male Middle Aged Questionnaires Risk Tunica Intima / ultrasonography* Tunica Media / ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients.
Next Document: The polycystic ovary post-rotterdam: a common, age-dependent finding in ovulatory women without meta...