| Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. | |
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MedLine Citation:
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PMID: 22210315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease. |
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Authors:
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Marcel Marquez; Marlène Huyvaert; John R B Perry; Richard D Pearson; Mario Falchi; Andrew P Morris; Sidonie Vivequin; Stéphane Lobbens; Loïc Yengo; Stefan Gaget; Francois Pattou; Odile Poulain-Godefroy; Guillaume Charpentier; Lena M S Carlsson; Peter Jacobson; Lars Sjöström; Olivier Lantieri; Barbara Heude; Andrew Walley; Beverley Balkau; Michel Marre; Philippe Froguel; Stéphane Cauchi; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-12-30 |
Journal Detail:
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Title: Diabetes Volume: 61 ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-25 Completed Date: 2012-03-13 Revised Date: 2012-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 524-30 Citation Subset: AIM; IM |
Affiliation:
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UMR CNRS 8199, Genomic and Metabolic Disease, Lille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
/
etiology,
genetics* Genome-Wide Association Study Genotype HMGA1a Protein / genetics* Humans Insulin Resistance Receptor, Insulin / genetics Risk |
| Chemical | |
Reg. No./Substance:
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124544-67-8/HMGA1a Protein; EC 2.7.10.1/Receptor, Insulin |
| Investigator | |
Investigator/Affiliation:
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Benjamin F Voight / ; Laura J Scott / ; Valgerdur Steinthorsdottir / ; Andrew P Morris / ; Christian Dina / ; Ryan P Welch / ; Eleftheria Zeggini / ; Cornelia Huth / ; Yurii S Aulchenko / ; Gudmar Thorleifsson / ; Laura J McCulloch / ; Teresa Ferreira / ; Harald Grallert / ; Najaf Amin / ; Guanming Wu / ; Cristen J Willer / ; Soumya Raychaudhuri / ; Steve A McCarroll / ; Claudia Langenberg / ; Oliver M Hofmann / ; Josée Dupuis / ; Lu Qi / ; Ayellet V Segrè / ; Mandy van Hoek / ; Pau Navarro / ; Kristin Ardlie / ; Beverley Balkau / ; Rafn Benediktsson / ; Amanda J Bennett / ; Roza Blagieva / ; Eric Boerwinkle / ; Lori L Bonnycastle / ; Kristina Bengtsson Boström / ; Bert Bravenboer / ; Suzannah Bumpstead / ; Noël P Burtt / ; Guillaume Charpentier / ; Peter S Chines / ; Marilyn Cornelis / ; David J Couper / ; Gabe Crawford / ; Alex S F Doney / ; Katherine S Elliott / ; Amanda L Elliott / ; Michael R Erdos / ; Caroline S Fox / ; Christopher S Franklin / ; Martha Ganser / ; Christian Gieger / ; Niels Grarup / ; Todd Green / ; Simon Griffin / ; Christopher J Groves / ; Candace Guiducci / ; Samy Hadjadj / ; Neelam Hassanali / ; Christian Herder / ; Bo Isomaa / ; Anne U Jackson / ; Paul R V Johnson / ; Torben Jørgensen / ; Wen H L Kao / ; Norman Klopp / ; Augustine Kong / ; Peter Kraft / ; Johanna Kuusisto / ; Torsten Lauritzen / ; Man Li / ; Aloysius Lieverse / ; Cecilia M Lindgren / ; Valeriya Lyssenko / ; Michel Marre / ; Thomas Meitinger / ; Kristian Midthjell / ; Mario A Morken / ; Narisu Narisu / ; Peter Nilsson / ; Katharine R Owen / ; Felicity Payne / ; John R B Perry / ; Ann-Kristin Petersen / ; Carl Platou / ; Christine Proença / ; Inga Prokopenko / ; Wolfgang Rathmann / ; N William Rayner / ; Neil R Robertson / ; Ghislain Rocheleau / ; Michael Roden / ; Michael J Sampson / ; Richa Saxena / ; Beverley M Shields / ; Peter Shrader / ; Gunnar Sigurdsson / ; Thomas Sparsø / ; Klaus Strassburger / ; Heather M Stringham / ; Qi Sun / ; Amy J Swift / ; Barbara Thorand / ; Jean Tichet / ; Tiinamaija Tuomi / ; Rob M van Dam / ; Timon W van Haeften / ; Thijs van Herpt / ; Jana V van Vliet-Ostaptchouk / ; G Bragi Walters / ; Michael N Weedon / ; Cisca Wijmenga / ; Jacqueline Witteman / ; Richard N Bergman / ; Stephane Cauchi / ; Francis S Collins / ; Anna L Gloyn / ; Ulf Gyllensten / ; Torben Hansen / ; Winston A Hide / ; Graham A Hitman / ; Albert Hofman / ; David J Hunter / ; Kristian Hveem / ; Markku Laakso / ; Karen L Mohlke / ; Andrew D Morris / ; Colin N A Palmer / ; Peter P Pramstaller / ; Igor Rudan / ; Eric Sijbrands / ; Lincoln D Stein / ; Jaakko Tuomilehto / ; Andre Uitterlinden / ; Mark Walker / ; Nicholas J Wareham / ; Richard M Watanabe / ; Goncalo R Abecasis / ; Bernhard O Boehm / ; Harry Campbell / ; Mark J Daly / ; Andrew T Hattersley / ; Frank B Hu / ; James B Meigs / ; James S Pankow / ; Oluf Pedersen / ; H-Erich Wichmann / ; Inês Barroso / ; Jose C Florez / ; Timothy M Frayling / ; Leif Groop / ; Rob Sladek / ; Unnur Thorsteinsdottir / ; James F Wilson / ; Thomas Illig / ; Philippe Froguel / ; Cornelia M van Duijn / ; Kari Stefansson / ; David Altshuler / ; Michael Boehnke / ; Mark I McCarthy / |
| Comments/Corrections | |
Comment In:
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Diabetes. 2012 May;61(5):e3
[PMID:
22517660
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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